20例糖尿病的胃粘膜微血管超微结构观察

目的 :通过对胃粘膜超微结构观察 ,了解糖尿病人胃粘膜微血管及胃固有腺体的变化特点 ,探讨胃粘膜微血管的变化与糖尿病胃病及其它重要合并症的联系。方法 :选择2 0例临床没有或仅有轻微症状的NIDDM病人 ,4例无糖尿病及胃病的志愿者作对照组 ,取胃窦部及胃体部粘膜组织各二份 ,进行透射电镜观察。结果 :全部被观察病例微血管内皮细胞均有不同程度的肿胀 ,基底膜增厚。微血管轻度变化 2例 ,中度变化 16例 ,重度变化 2例。壁细胞内线粒体数目不同程度地减少 ,部分线粒体肿胀 ,少数线粒体高度肿胀、脊断裂 ,壁细胞分泌小管减少或萎缩。10例有 1种以上合并症者 (糖尿病肾病、视网膜病变、神经病变 )微血管损伤均在中度以上。结论 :糖尿病胃粘膜微血管的损伤是糖尿病性胃病的重要病理基础。

Ultrastructural observance of 20 cases microvascular in gastric mucosa of NIDDM

Objective: In order to study the relationship between diabetic gastropathy and microvascular.Method: The gastric mucosa in 20 cases with non￣insulin dependent diabetes mellitus (NIDDM) were observed by electric microscope, compared with the group (4 cases) without diabetes mellitus. Results: It was found that all cases of microvascular endothelicytes got swelling and basal menbrance got thick in varying degrees. The microvascular mild injuring has 2 cases, and medial injuring has 16 cases, and 2 cases were injures seriously, and the group (4 cases) compared were normal. The 10 cases had over one complication (diabetic nephropathy, retinopathy, neuropathy) that its microvascular injuring was more serious than medial injuring.Conclusion: The results show that microvascular injuring in gastric mucosa with NIDDM is pathologic basis of diabetic gastropathy.