右美托咪定诱导麻醉对高血压脑出血患者脑功能的影响

目的分析研究右美托咪定诱导麻醉对高血压脑出血患者术中体征及术后脑功能的影响。方法选取我院2015-02—2017-02收治的88例高血压脑出血患者进行研究,随机分为对照组和观察组各44例。观察组在麻醉诱导前静脉给予右美托咪定治疗,对照组给予等量的生理盐水,对比2组不同时间点HR、SBP、DBP、MAP水平及不良反应发生情况和术后脑功能恢复情况。结果 2组患者入室时各指标相比差异无统计学意义(P0.05),在诱导前、插管后、切皮时及自主呼吸恢复时各时间点的HR、SBP、DBP、MAP水平等指标均显著低于对照组(P0.05);2组患者术前S100β蛋白水平及NSE水平相比差异无统计学意义(P0.05),但观察组术后0h、术后6h、术后12h、术后24h各时间点均显著低于对照组,2组相比差异均有统计学意义(P0.05);观察组术后不良反应发生率显著高于对照组(P0.05)。结论右美托咪定诱导麻醉可以有效改善患者的心率和血压,同时可以维持患者血流动力学指标的稳定,且对患者脑功能具有保护作用,值得临床推广。

Effects of dexmedetomidine-induced anesthesia on intraoperative signs and postoperative brain function in patients with hypertensive intracerebral hemorrhage

Objective To investigate the effects of dexmedetomidine-induced anesthesia on intraoperative signs and postoperative brain function in patients with hypertensive intracerebral hemorrhage.Methods 88 patients with hypertensive intracerebral hemorrhage in our hospital from February 2002 to February 2017 were randomly divided into control group (n=44) and observation group (n=44).The patients in the observation group were given intravenous administration of dexmedetomidine before anesthesia induction.The patients in the control group were given the same amount of normal saline.The levels of HR,SBP,DBP and MAP,adverse reactions and postoperative recovery of brain function were observed at different points between two groups.Results No significant differences were found between the two groups when patients entered the operation room (P>0.05).Before induction,after intubation,at the time of skin incision and at the different points when autonomous respiration recovered,the levels of HR,SBP,DBP and MAP in the observation group were significantly lower than those in the control group (P<0.05).The level of S100β protein and NSE between two groups before treatment showed no statistical differences (P>0.05),0 h,6 h,12 h and 24 h after operation which were remarkably lower in the observation group (P<0.05).The incidence of adverse reactions in the observation group was significantly higher than that in the control group (P<0.05).Conclusion Deemethasone-induced anesthesia can effectively improve the patients' heart rate and blood pressure,maintain the stability of hemodynamic parameters and have a protective effect on brain function,which should be worthy of clinical promotion.