奥卡西平联合银杏达莫注射液对癫痫患儿的作用机制研究

目的探讨奥卡西平联合银杏达莫注射液对癫痫患儿T淋巴细胞亚群及血清碱性磷酸酶(ALP)、细胞间黏附分子1(ICAM-1)水平变化的影响。方法选取洛阳市妇女儿童医疗保健中心77例癫痫患儿,按照随机数字表法分组,对照组38例予以单一奥卡西平治疗,观察组39例给予奥卡西平+银杏达莫注射液治疗,观察2组临床治疗效果、T淋巴细胞亚群(CD3+、CD4+、CD8+)及血清ALP、ICAM-1水平变化情况,并统计2组不良反应发生情况及生活质量评分。结果观察组总有效率94.87%(37/39),高于对照组的71.05%(27/38),差异有统计学意义(P0.05)。治疗3个月后观察组CD3+及CD4+均高于对照组,CD8+低于对照组,差异有统计学意义(P0.05)。治疗3个月后2组血清ALP水平比较,差异无统计学意义(P0.05),观察组血清ICAM-1水平低于对照组,差异有统计学意义(P0.05)。观察组不良反应发生率15.38%(6/39),对照组为10.53%(4/38),差异无统计学意义(P0.05)。治疗3个月后观察组社会能力、认知功能、总体健康、生活质量、药物影响、精神健康及生活满意度评分均高于对照组,差异有统计学意义(P0.05)。结论银杏达莫注射液辅助奥卡西平治疗癫痫效果显著,安全性高,可改善患儿血清ICAM-1水平及T淋巴细胞亚群,提高其生活质量。

Study on the mechanism of oxcarbazepine combined with ginkgo dipyridium injection on children with epilepsy

Objective To investigate the effect of oxcarbazepine combined with ginkgo dipyridamole injection on T lympho-cyte subsets,serum alkaline phosphatase (ALP)and intercellular adhesion molecule-1 (ICAM-1)levels in children with epilepsy. Methods A total of 77 children with epilepsy in Luoyang Women and Children′s Health Care Center were randomly divided into control group (n =38)and observation group (n =39).The control group was treated with single oxcarbazepine,the observation group was treated with oxcarbazepine + ginkgo dipyridamole injection.The clinical treatment effect,T lymphocyte subsets (CD3 + ,CD4 + ,CD8 + )and serum ALP and ICAM-1 levels were observed and compared between the two groups and the incidence of adverse reactions and quality of life scores were statistically analyzed.Results The total effective rate in the observation group (94.87％,37/39)was higher than that in the control group (71.05％,27/38),the difference was statistically significant (P <0.05).T lymphocyte subsets:CD3 + and CD4 + in the observation group were higher than those in the control group after 3 months of treatment,while CD8 + was lower than that of the control group,the difference was statistically significant (P <0.05 ).There was no significant difference in serum ALP level between the two groups after 3 months of treatment (P >0.05),while the serum ICAM-1 level in the observation group was lower than that in the control group,the difference was statistically significant (P <0.05).The incidence of adverse reactions in the observation group was 15.38％ (6/39),the control group was 10.53％ (4/38), the difference was not statistically significant (P >0.05).After 3 months of treatment,the social competence,cognitive function, overall health,quality of life,drug effects,mental health and life satisfaction scores of the observation group were higher than those of the control group,the difference was statistically significant (P < 0.05 ).Conclusion Oxcarbazepine combined with ginkgo dipyridium injection in the treatment of epilepsy have a significant efficacy,with higher safety,which can improve the serum ICAM-1 level and T lymphocyte subsets and improve the quality of life.