妊娠期高血压疾病与新生儿缺氧缺血性脑病的相关性研究

目的分析妊娠期高血压疾病与新生儿缺氧缺血性脑病的相关性。方法选取我院2015-11—2016-12收治的46例缺氧缺血性脑病新生儿为观察组,纳入同期46例健康足月胎龄儿为对照组,比较2组新生儿母亲重度子痫前期、子痫发作率及血压情况,并将观察组患儿根据影像学检查结果分为重度组、中度组和轻度组,比较3组患儿母亲妊娠期血压水平、重度子痫前期及子痫发作率。结果观察组母亲重度子痫前期及子痫发作率均高于对照组,差异有统计学意义(P0.05);2组舒张压比较无明显差异(P0.05),观察组平均收缩压(SBP)高于对照组,差异有统计学意义(P0.05);与中度组、轻度组比较,重度组母亲妊娠期血压水平、重度子痫前期及子痫发作率较高,且中度组重度子痫前期及子痫发作率(29.41%、11.76%)高于轻度组(15.00%、0),差异有统计学意义(P0.05),但中度组、轻度组母亲妊娠期血压比较无明显差异(P0.05)。结论妊娠期高血压是导致新生儿缺氧缺血性脑病的危险因素,可增加其发病率,及时发现妊娠期高血压,并给予相应治疗与血压控制,对预防新生儿缺氧缺血性脑病和提高预后具有重要意义。

Study on the relationship between hypertensive disorder complicating pregnancy and hypoxic-ischemic encepha-lopathy in neonates

Objective To analyze the relationship between hypertensive disorder complicating pregnancy and neonatal hy-poxic-ischemic encephalopathy.Methods Forty-six children with neonatal hypoxic-ischemic encephalopathy from November 2015 to December 2016 were selected as observation group in our hospital,and 46 cases of healthy full term for gestational age were set as control group.The occurrence rate of newborn mothers with severe preeclampsia,eclampsia and the levels of maternal blood pressure were statistically compared between the two groups.The observation group was divided into severe group,moderate group and mild group according to the imaging findings,and the mean blood pressure during pregnancy,occurrence rates of severe preeclampsia and eclampsia of three groups were statistically compared.Results The occurrence rates of severity preeclampsia and eclampsia in the observation group were higher than those in the control group (P <0.05).There was no significant difference in diastolic blood pressure between the two groups (P >0.05),the mean systolic blood pressure (SBP)in the observation group was higher than that in the control group,the difference was statistically significant (P <0.05 ).Compared with the moderate group and mild group,the average blood pressure during pregnancy and the occurrence rates of severe preeclampsia and eclampsia of se-vere group were higher,and the occurrence rates of severe preeclampsia and eclampsia in the moderate group (29.41％,11.76％) were significantly higher than those in the mild group (15.00％,0),the difference was statistically significant (P <0.05).Howev-er,there was no difference in blood pressure between the moderate and the mild group (P >0.05).Conclusion Hypertensive dis-ease in pregnancy is the risk factor of neonatal hypoxic-ischemic encephalopathy,which can increase the neonatal morbidity.Timely detection of the hypertensive disease in pregnancy and early therapeutic intervention are of great significance for the prevention and prognosis of neonatal hypoxic-ischemic encephalopathy.