肺癌合并脑梗死的危险因素分析

目的探讨肺癌合并脑梗死的危险因素。方法选取我院2014-01—2016-07收治的43例肺癌合并脑梗死患者为观察组,选取同期来我院诊治的45例单纯脑梗死患者(对照1组)和45例单纯肺癌患者(对照2组)进行对照观察,比较分析3组的分型、年龄、实验室检查结果等。结果 3组年龄、性别比较差异无统计学意义(P0.05),高血压史、高脂血症病史、糖尿病史比较差异有统计学意义(P0.05);血常规检验、凝血功能、临床症状、体征、D-二聚体比较差异均有统计学意义(P0.05);观察组与对照1组神经功能缺损评分比较,与对照2组肺癌分型比较,差异均无统计学意义(P0.05);观察组CA199、CA125指标值均高于对照2组(P0.05);多因素回归分析显示,D-二聚体、CA199、CA125为独立危险因素(P0.05)。结论 D-二聚体过高、CA199和CA125过高是肺癌患者引发脑梗死的独立危险因素,临床应加强对肺癌患者的相关检查,及时采取干预措施,预防脑梗死发生。

Clinical characteristics of lung cancer complicated with cerebral infarction

Objective To explore the clinical characteristics of lung cancer combined with cerebral infarction.Methods The clinical data from 43 cases with lung cancer and cerebral infarction selected as observation group in our hospital from January 2014 to July 2016 were analyzed retrospectively.And at the same time 45 cases only with cerebral infarction were enrolled as control group (infarction group) and 45 cases only with lung cancer were recruited as another control group (cancer group).We comparatively analyzed pathologic type of lung cancer,age and laboratory tests in the three groups.Results Among the three groups,there were no differences in age and gender,but significant differences were found in histories of hypertension,hyperlipidemia and diabetes (all P<0.05).Additionally,blood routine,coagulation function,clinical symptoms,physical signs and D-dimer showed statistical differences (all P<0.05).When we compared observation group and infarction group,the neurological functional deficit scores displayed important difference (P<0.05),and compared with cancer group,the pathologic type of lung cancer in the observation group indicated significant difference (P<0.05).Furthermore,the levels of CA199 and CA125 in the observation group were significantly higher than those in the control groups (P<0.05).Multi-factor regression analysis showed that the D-dimer,CA199 and CA125 were the independent factors (P<0.05).Conclusion The high levels of D-dimer,CA199 and CA125 are the independent factors for lung cancer complicated with cerebral infarction,so clinical workers should pay attention to give the related examination and carry out interventional measures in time to precaution the occurrence of cerebral infarction.