OSAHS患者血清LCN-2、Lipin1水平和胰岛素抵抗的关系

目的研究阻塞性睡眠呼吸暂停综合征(OSAHS)患者血清脂质运载蛋白2(LCN-2)、脂素蛋白1(Lipin1)水平和胰岛素抵抗的关系。方法根据睡眠呼吸监测数据,将患者分为轻度OSAHS组、中度OSAHS组、重度OSAHS组和正常对照组,检测并比较各组血清LCN-2、Lipin1和胰岛素抵抗指数(HOMA-IR)等生化指标,并研究其相关性。结果重度OSAHS组、中度OSAHS组患者较正常对照组血清LCN-2和HOMA-IR升高、Lipin1降低,差异有统计学意义(P0.05);重度OSAHS组较轻度OSAHS组LCN-2和HOMA-IR升高、Lipin1降低,差异有统计学意义(P0.05);LCN-2与BMI、LDL-C、HOMA-IR呈正相关;Lipin1与BMI、LDL-C、HOMA-IR呈负相关;多元线性相关分析示AHI与腰围、HOMA-IR、LCN-2和Lipin1有线性回归关系,其中与Lipin1负相关。结论 OSAHS患者可能通过升高LCN-2及降低Lipin1引起胰岛素抵抗。

Correlations of serum LCN-2 and Lipin1 levels with insulin resistance in OSAHS patients

Objective To investigate the correlations of serum Lipocalin-2 (LCN-2) and Lipin1 levels with insulin resistance in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods According to sleep respiratory monitoring data,all participants were divided into the mild group,moderate group,severe group and normal control group.We tested the serum LCN-2 level,Lipin1 level and insulin resistance index (HOMA-IR) and then explored their relations.Results Compared with control group,the moderate group and the severe group showed high levels of LCN2 and HOMA-IR and lower level of Lipin1 (P<0.05).Both LCN2 and HOMA-IR levels were high and Lipin1 level was lower in the severe group compared with those in the mild group (P<0.05).LCN-2 level had positive correlations with BMI,LDL-C and HOMA-IR levels and Lipin1 level had negative correlations with BMI,LDL-C and HOMA-IR levels.Multiple linear regression showed that linear regression relations existed between AHI and waist circumference,HOMA-IR level,LCN-2 level and Lipin1 level,and showed that AHI was negatively correlated with Lipin1 level.Conclusion OSAHS patients suffer insulin resistance which may be caused by the increased LCN-2 level and the decreased Lipin1 level.