阿司匹林与氯吡格雷双联对TIA患者凝血功能的影响

目的探讨阿司匹林与氯吡格雷双联对短暂性脑缺血发作(TIA)患者血小板聚集率和纤维蛋白原的影响。方法100例短暂性脑缺血发作患者随机分为2组,在常规控制血压、血糖、血脂等基础上,治疗组给予阿司匹林联合氯吡格雷治疗,对照组给予阿司匹林,其中阿司匹林100mg/d,氯吡格雷75mg/d。观察2组血小板聚集率与纤维蛋白原相关指标及临床疗效。结果治疗7~14d后,与对照组比较,治疗组血小板聚集率显著改善(P0.05),纤维蛋白原水平下降更显著(P0.05);治疗组临床疗效显著优于对照组(P0.05)。2组均未出现严重出血并发症。结论阿司匹林与氯吡格雷双联治疗短暂性脑缺血发作可改善患者血小板聚集率,降低纤维蛋白原水平,临床疗效显著。

Effect of aspirin and clopidogrel on platelet aggregation rate and fibrinogen in patients with transient ischemic attack

Objective To investigate the effect of aspirin and clopidogrel on platelet aggregation rate and fibrinogen in patients with transient ischemic attack.Methods Based on the normal control of blood pressure,blood sugar and blood fat,100 patients with TIA were randomly distributed into aspirin and clopidogrel combined group (treatment group) and aspirin group (control group) under the condition of 100 mg/d aspirin and 75 mg/d clopidogrel.Then related indexes of platelet aggregation rate and fibrinogen and clinical effects were observed.Results After the treatment of 7-14 days,the improvement of platelet aggregation rate was statistically significant in the treatment group (P＜0.05);the decrease of fibrinogen level was more evident (P＜0.05).Clinical effects of treatment group was much better than control group (P＜0.05).Neither of the two groups had a serious hemorrhagic complication.Conclusion Aspirin and clopidogrel in the treatment of TIA can improve platelet aggregation rate and decrease fibrinogen level,with an evident clinical effect.