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Insulin-like growth factor binding protein-3 in breast cyst fluid: relationships with insulin-like growth factors I and II and transforming growth factor-beta 1 and 2 |
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| Authors: | L. C. Lai H. Erbas K. A. Meadows T. W. J. Lennard J. M. P. Holly |
| Affiliation: | a Department of Clinical Biochemistry, Freeman Hospital, Freeman Road, Newcastle upon Tyne, NE7 7DN, UK b Department of Surgery, Bristol Royal Infirmary, Marlborough Street, Bristol, UK c Department of Surgery, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK |
| Abstract: | Women who have palpable breast cysts with intracystic Na/K > 3 may have a lower risk of developing breast cancer than those with intracystic Na/K < 3. In this study significantly higher concentrations of insulin-like growth factor-binding protein-3 (IGFBP-3), insulin-like growth factors I and II (IGF-I, IGF-II) and transforming growth factor-beta 2 (TGF-β2) were found in the Na/K > 3 sub-group. No difference was found in transforming-growth factor-beta 1 (TGF-β2) levels between the two sub-groups of breast cysts. A positive correlation was obtained for IGFBP-3 and TGF-β1 in the Na/K > 3 sub-group consistent with reports that TGF-β1 may regulate the production of IGFBP-3. Equimolar amounts of total IGFs and IGFBP-3 in breast cyst fluid imply that most, if not all, of these IGFs are protein-bound. The significantly higher concentrations of TGF-β2 in the Na/K > 3 sub-group may partly explain the lower risk of breast cancer in this group of women. |
| Keywords: | Insulin-like growth factor I (IGF-I) Insulin-like growth factor I (IGF-II) Insulin-like growth factor-binding protein-3 (IGFBP-3) Transforming-growth factor-beta 1 (TGF-β1) Transforming growth factor-beta 2 (TGF-β2) Breast cyst fluid |
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