Congenital medulloblastoma: an inquiry into origins |
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| Authors: | A. Loren Amacher Quirico U. Torres Susan Rittenhouse |
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| Affiliation: | (1) Division of Neurosurgery, University of Connecticut School of Medicine, 06115 Hartford, CT, USA;(2) Department of Neurosurgery and Pathology, Hartford Hospital, 06115 Hartford, CT, USA;(3) 85 Jefferson Street, 06106 Hartford, CT, USA |
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| Abstract: | An infant aged 8 h died from cardiorespiratory causes. At autopsy, a microscopic midline cerebellar medulloblastoma was found. Neoplastic cells occurred within the fetal external granular cell layers, with invasion of perivascular spaces as well as the molecular and internal granular cell layers. This extremely rare occurrence lends support to the hypothesis that cerebellar medulloblastoma occurring in older patients originates within retained rests of primitive cells in the fetal external granular cell layer. |
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| Keywords: | Cerebellar medulloblastoma Congenital Primitive neuroectodermal cell rests |
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