| RNA干扰与肿瘤的基因治疗 |
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| 引用本文： | 薛祥云,尤永平,刘宁.RNA干扰与肿瘤的基因治疗[J].中华神经医学杂志,2005,4(3):317-319. |
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| 作者姓名： | 薛祥云 尤永平 刘宁 |
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| 作者单位： | 1. 南京医科大学
2. 210029,南京医科大学附属医院神经外科 |
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| 摘 要： | RNA干扰(RNAi)是指双链RNA(dsRNA)在细胞内特异性诱导同源互补的mRNA降解,从而阻断相应基因表达的现象.随着哺乳动物RNA干扰的研究不断取得进展,RNA干扰显示出作为一种新型肿瘤基因治疗方法的巨大优越性.初步的实验结果表明,用RNA干扰治疗癌症的设想有可能变成现实.
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| 关 键 词： | RNA干扰 肿瘤 基因治疗方法 mRNA 哺乳动物 基因表达 治疗癌症 性诱导 细胞内 优越性 |
| 文章编号： | 1671-8925(2005)03-317-003 |
| 修稿时间： | 2004年6月7日 |
RNA interference and tumor gene therapy |
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| XUE Xiang-yun,YOU Yong-ping,LIU Ning.RNA interference and tumor gene therapy[J].Chinese Journal of Neuromedicine,2005,4(3):317-319. |
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| Authors: | XUE Xiang-yun YOU Yong-ping LIU Ning |
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| Abstract: | RNA interference (RNAi) refers to homologous complementary mRNA degradation induced specifically by double-stranded RNA, which actually interdicts the expression of corresponding genes. The continual development of the study on mammiferous RNAi shows its tremendous advantage as a novel genetic therapeutic technique on tumor. Pilot studies have indicated that tentative plan of treating tumor by RNAi technology may be turned into reality. |
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| Keywords: | RNA Neoplasms Genetic therapy |
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