| 天麻素与天麻苷元的镇痛作用研究 |
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| 引用本文： | 张怡评,林丽聪,吴春敏. 天麻素与天麻苷元的镇痛作用研究[J]. 福建中医学院学报, 2006, 16(6): 30-31 |
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| 作者姓名： | 张怡评 林丽聪 吴春敏 |
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| 作者单位： | 1. 福建中医学院药学系,福建,福州,350108
2. 福建省药品检验所,福建,福州,350001 |
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| 摘 要： | 比较不同剂量天麻素与天麻苷元的镇痛作用,阐明石仙桃镇痛有效成分。采用热板法、醋酸扭体法观察不同剂量天麻素与天麻苷元的镇痛作用。结果:不同剂量天麻素与天麻苷元均能显著提高热板法致痛小鼠的痛阈,明显抑制醋酸引起的小鼠扭体反应,且呈剂量依赖性。结论:天麻素与天麻苷元均具有镇痛效果,为石仙桃镇痛有效成分。
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| 关 键 词： | 天麻素 天麻苷元 镇痛 热板 扭体 |
| 文章编号： | 1004-5627(2006)06-0030-02 |
| 修稿时间： | 2006-09-12 |
Evaluation on Analgesic Effects of Gastrodine and 4-Hydroxybenzyl Alcohol |
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| ZHANG Yi-ping,LIN Li-cong,WU Chun-min. Evaluation on Analgesic Effects of Gastrodine and 4-Hydroxybenzyl Alcohol[J]. Journal of Fujian College of Traditional Chinese Medicine, 2006, 16(6): 30-31 |
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| Authors: | ZHANG Yi-ping LIN Li-cong WU Chun-min |
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| Abstract: | To evaluate the analgesic effects of different dosages of gastrodine and 4-hydroxybenzyl alcohol by hot-plate test and writhing response,and illuminate the effective compounds of Pholidota chinensis Lind1.The results showed that different dosages of gastrodine and 4-hydroxybenzyl alcohol could prolong the time of hot-plate response in mice,and reduce the numbers of writhing induced by acetic acid.Conclusion: Gastrodine and 4-hydroxybenzyl alcohol are of certain analgesic effect in a dose-dependent manner,and they are the analgesic effective compounds of Pholidota chinensis Lind1. |
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| Keywords: | gastrodine 4-hydroxybenzyl alcohol analgesic effect hot-plate test writhing response |
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