我院抗结核药致不良反应92例报告分析

目的:总结常用抗结核药的不良反应,为临床合理用药提供参考。方法:对我院2010-2013年肺结核病患者在抗结核治疗中出现药品不良反应(ADR)的92例患者的临床资料进行回顾性分析。结果:92例患者中,男性63例(68.48%),女性29例(31.52%);口服给药引发的ADR最多,有71例(77.17%);ADR以肝功能损害(32.61%)为主,其次是过敏反应(27.17%)。结论:抗结核药的ADR发生率较高,以肝功能损害、过敏反应为最常见,临床应引起重视。

Analysis of 92 Cases Antitubercular Agent-induced ADR Reports in Our Hospital

OBJECTIVE： To summarize common antitubercular agent-induced ADR, and to provide reference for rational drug use in the clinic. METHODS ： The clinical information of 92 tuberculosis patients suffering from ADR during antitubercular therapy in our hospital during 2010--2013 were analyzed retrospectively. RESULTS： Among 92 patients, there were 63 male （68.48%） and 29 female （31.52%） ; 77.17% （71 cases） of the ADR cases were induced by oral administration; ADR mainly manifested as liver injury （32.61%）, followed by allergic reaction （27.17%）. CONCLUSIONS： The incidence of antitubercular agent-induced ADR is high, and liver function and allergic reaction are the most common ADR. Great importance should be attached to these.