辛伐他汀联合鲑鱼降钙素及碳酸钙D_3治疗老年性骨质疏松症的临床观察

目的:观察辛伐他汀联合鲑鱼降钙素及碳酸钙D3治疗老年性骨质疏松症(OP)的临床疗效和安全性。方法:341例老年性OP患者按随机数字表法分为对照组(170例)和观察组(171例)。在一般治疗的基础上,对照组患者给予碳酸钙D3600 mg,口服,qd+阿仑膦酸钠70 mg,口服,每周1次;观察组患者给予辛伐他汀20 mg,口服,qd+碳酸钙D3600 mg,口服,qd+鲑鱼降钙素50U,肌肉注射,qd,连用l周后改为50 U隔天1次,连用2周后改为50 U每周2次。两组患者疗程均为6个月。对比两组患者疼痛改善情况及临床疗效,并观察不良反应情况。结果:两组共325例患者完成疗程(对照组161例,观察组164例)。治疗前两组患者自发腰背疼痛、前屈后伸痛、翻身痛及负重痛的视觉模拟评分法(VAS)评分比较,差异均无统计学意义(P>0.05);治疗后两组患者各项VAS评分均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:辛伐他汀联合鲑鱼降钙素及碳酸钙D3治疗老年性OP的临床疗效优于碳酸钙D3联合阿仑膦酸钠,可有效改善和提高骨密度水平,缓解临床疼痛症状,安全性较好。

Clinical Observation of Simvastatin Combined with Calcitonin and Caltrate D3 Tablet in the Treatment of Se- nile Osteoporosis

OBJECTIVE： To observe clinical efficacy and safety of simvastatin combined with calcitonin and Caltrate D3 tab- let in the treatment of senile osteoporosis （OP）. METHODS： 341 senile OP patients were randomly divided into observation group （171 cases） and control group （170 cases）. On the basis of general treatment, control group was given Caltrate D3 tablet 600 mg, qd＋alendronate 70 mg, once a week, orally; observation group received simvastatin 20 mg orally, qd＋Caltrate D3 tablet 600 mg orally, qd＋intramuscular injection of calcitonin 50 U, qd, one week later every other day, 2 weeks later twice a week. Treatment course of 2 groups lasted for 6 months. The improvement of pain and clinical efficacy were compared between 2 groups, and ADR was observed. RESULTS： A total of 325 patients completed treatment in 2 groups （161 cases in control group, 164 cases in obser- vation group）. There was no statistical significance in VAS score of spontaneous back pain, flexion extension pain, turning over pain and weight-bearing pain between 2 groups before treatment （P〉0.05）. VAS score of 2 groups after treatment were significant- ly lower than before; the observation group was significantly lower than the control group; there was statistical significance （P〈 0.05）. Total effective rate of observation group was significantly higher than that of control group; there was statistical significance （P〈0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P〉0.05）. CONCLUSIONS： Simvas- tatin combined with calcitonin and Caltrate D3 tablet is better than Caltrate D3 tablet combined with alendronate for senile OP in clini- cal efficacy and safety; it can improve bone density and relieve pain effectively.