青鹏软膏治疗乏脂性湿疹疗效和皮肤屏障功能影响的自身对照研究

目的 探讨青鹏软膏治疗乏脂性湿疹的疗效，以及对皮肤屏障功能的影响。 方法 对78例双下肢对称分布的乏脂性湿疹患者，采取自身对照方法，青鹏软膏组左下肢外用青鹏软膏，丁酸氢化可的松组右下肢外用丁酸氢化可的松乳膏，每日2次，连续治疗4周，比较其疗效及皮肤屏障功能的变化。 结果 治疗1、2周时，青鹏软膏组的有效率低于丁酸氢化可的松组，差异有统计学意义（1周：39.74%比58.97%，χ2 = 5.77，P < 0.05；2周：60.26%比76.92%，χ2 = 5.03，P < 0.05），但治疗4周时，青鹏软膏组和丁酸氢化可的松组有效率（80.77%比87.18%）差异无统计学意义（P > 0.05）。治疗4周，青鹏软膏组角质层含水量显著高于对丁酸氢化可的松组（P < 0.05），而治疗2、4周时，青鹏软膏组TEWL值显著低于丁酸氢化可的松组（均P < 0.05）。 结论 青鹏软膏治疗乏脂性湿疹安全、有效，作用稳定，利于皮肤屏障功能的修复。

Efficacy of Qingpeng ointment for the treatment of asteatotic eczema and its effect on skin barrier function: a self-controlled clinical study

Objective To evaluate the efficacy of Qingpeng ointment for the treatment of asteatotic eczema and its effect on skin barrier function.Methods A self-controlled clinical study was performed.Totally,78 patients with asteatotic eczema symmetrically located on both lower extremities were enrolled into this study.The left and right lower extremities of these patients were treated with Qingpeng ointment (Qingpeng group) and hydrocortisone butyrate ointment (hydrocortisone butyrate group) respectively,twice a day for 4 consecutive weeks.At the end of treatment,therapeutic effect and skin barrier function were compared between the 2 groups.Results The response rate was significantly higher in the hydrocortisone butyrate group than in the Qingpeng group after 1-and 2-week treatment (week 1:58.97％ vs.39.74％,x2 =5.77,P ＜ 0.05;week 2:76.92％ vs.60.26％,x2 =5.03,P ＜ 0.05),but insignificantly different between the 2groups after 4-week treatment (80.77％ vs.87.18％,P ＞ 0.05).Compared with the hydrocortisone butyrate group,theQingpeng group showed significantly increased water content of the stratum corneum after 4-week treatment (P ＜ 0.05),and decreased transepidermal water loss after 2-and 4-week treatment (both P ＜ 0.05).Conclusion Qingpeng ointment is safe and effective for the treatment of asteatotic eczema with gradually increasing and stable effects,and also has a favoring effect on the restoration of skin barrier function.