多囊卵巢综合征患者血清胃促生长素水平检测的临床意义

目的：探讨多囊卵巢综合征（PCOS）患者血清胃促生长素（Ghrelin）水平检测的临床意义。方法：选用 PCOS患者61例作为观察组，选取月经正常的避孕妇女60例作为对照组，检测两组Ghrelin、卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、睾酮（T）及空腹血糖（FBG）、空腹胰岛素（FIN）等指标，计算胰岛素抵抗指数（HOMA-IR），并根据体质指数（BMI）将PCOS患者分为肥胖组和正常组，比较两组上述指标的关系。结果：①观察组LH、T、HOMA-IR指标均显著高于对照组，其差异有统计学意义（P＜0.05）；观察组Ghrelin指标显著低于对照组，其差异亦具有统计学意义（P＜0.05）。②肥胖组LH、HOMA-IR 指标均显著高于正常组，其差异有统计学意义（P＜0.05）；肥胖组 Ghrelin 指标显著低于正常组，其差异亦具有统计学意义（P＜0.05）。③肥胖组LH、HOMA-IR指标与Ghrelin水平负相关（相关系数r分别为-0.785、-0.692，P＜0.05）。结论：血清胃促生长素能够作为多囊卵巢综合征的敏感检测指标，对其临床诊断和治疗均有重要意义。

Clinical significance of detection of serum ghrelin levels on polycystic ovary syndrome

Objective：To investigate clinical significance of detection of serum ghrelin levels on POCS. Methods：61 patients with PCOS were selected as the observation group, 60 women with normal menstruation contraception were selected as the control group, they were detected Ghrelin, follicle stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）, testosterone （T） and fasting blood glucose （FBG）, fasting insulin （FIN） and other indicators, insulin resistance index （HOMA-IR）, and according to body mass index （BMI） will be obese PCOS patients were divided into the obese group and the normal group, these indicators were compared relationships. Results：①Observation group’s LH, T, HOMA-IR index were significantly higher, the difference was statistically significant （P〈0.05）; Ghrelin index in observation group was significantly lower than that in the control group, the differences are statistically significant （P〈0.05）.②Obese group’s LH, HOMA-IR index were significantly higher than that in the normal group, the difference was statistically significant （P〈0.05）; Ghrelin index in obese group was significantly lower than that in the normal group, the difference was also statistically significant （P〈0.05）. ③Obese group’s LH, HOMA-IR index and Ghrelin levels negatively correlated （correlation coefficient r=-0.785, -0.692, P〈0.05）. Conclusion： Serum ghrelin sensitive detector can be used as indicators of polycystic ovary syndrome, the clinical diagnosis and treatment are important.