Assessment of insulin resistance in Chinese PCOS patients with normal glucose tolerance |
| |
| Authors: | Jing Gao Li Zhou Jie Hong |
| |
| Affiliation: | 1. Department of Gynecology and Obstetrics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China;2. Department of Gynecology and Obstetrics, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China;3. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China |
| |
| Abstract: | The study aimed to investigate insulin resistance (IR) status in polycystic ovary syndrome (PCOS) women with normal glucose tolerance (NGT), and further to evaluate feasible diagnostic method for those patients. Three hundred and twenty-five PCOS women with NGT and ninety-five healthy age-matched controls were recruited with Rotterdam criterion and 75 g oral glucose tolerance test (OGTT). IR status was estimated following a glycemic and insulinemic OGTT (0, 30, 60, 120, and 180 min). A modified HOMA-IR formula was applied to each time-course value of glycemia and insulinemia. The predictive performance of each IR index was analyzed with the use of ROC curves. Compared with healthy controls, both non-obese and obese PCOS patients with NGT had a higher BMI, serum glucose, insulin value (p?
|
| |
| Keywords: | Polycystic ovary syndrome (PCOS) insulin resistance (IR) oral glucose tolerance test (OGTT) normal glucose tolerance (NGT) |
|
|
