The Role of the CD8-Positive Subset of T Cells in Proliferative Responses to Soluble Antigens |
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| Authors: | Ø . BRUSERUD,L. SOLLID,G. GAUDERNACK,E. THORSBY |
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| Affiliation: | Institute of Transplantation Immunology, University of Oslo, and The National Hospital, Rikshospitalet, Oslo, Norway |
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| Abstract: | The role of CD8 (T8, Leu 2)-positive T lymphocytes in the proliferative T-lymphocyte response to mumps and Coxsackie B4 viral antigens in vitro was investigated. The frequency among enriched T-lymphocyte blasts of antigen-reactive T lymphocytes (ARTL) restricted by different DR-associated elements was investigated, using antigenic restimulation with allogeneic antigen-presenting cells in a limiting dilution assay. A decreased frequency of DR3-restricted and an increased frequency of DR4-restricted mumps and Coxsackie B4 ARTL were seen in the limiting dilution assay, whether or not HLA class I determinants were shared in the antigenic restimulation. Removal of CD8-positive cells did not increase the primary in vitro responsiveness to mumps and Coxsackie B4 viral antigens, and did not change the DR-associated differences in the frequency of ARTL seen in the limiting dilution assay. |
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