FⅦ活化蛋白酶基因的Marburg Ⅰ型多态性与脑梗死发病的相关性

目的：探讨FⅦ活化蛋白酶（Factor Ⅶ-activating protease,FSAP）基因的Marburg Ⅰ型多态性与脑梗死发病之间的相关性,并分析FSAP的Marburg I型多态性是否为脑梗死的危险因子之一。方法：应用单链构象多态性PCR技术（SSCP-PCR）,对159例临床确诊的脑梗死患者及179例年龄、性别相匹配的无血栓性疾病病史志愿者的FSAP基因进行多态性分析。结果：FSAP基因表型在病例组及对照组中均为野生型纯合子,未检测到Marburg Ⅰ型突变型。发现1例FSAP基因点突变（C1815T）。结论：FSAP基因的Marburg Ⅰ型多态性与脑梗死发病可能无相关性。

Marburg Ⅰ polymorphism of Factor Ⅶ-activating protease and cerebral infarction

Objective To determine the relation between Marburg I polymorphism of FactorⅦ-activating protease（FSAP）and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction.Methods Single strand conformation polymorphism-polymerase chain reaction（SSCP-PCR）was applied for the polymorphism analysis of FSAP in 159 patients with cerebral infarction and 179 non-cerebral infarction subjects.Results The phenotypes of FSAP in both the patients and the control subjects were wild type GG;no mutant of Marburg I was found.But a new gene mutation was tested,which had not been reported,requiring further investigation.Conclusion Marburg I polymorphism of FSAP may not be associated with cerebral infarction.