补肾活血泄浊汤治疗微小病变肾病的实验研究

目的:探讨中药补肾活血泄浊汤对大鼠微小病变肾病的治疗作用及其机制。方法：采用一次性尾静脉注射阿霉素法复制大鼠的微小病变肾病模型，分为补肾活血泄浊汤治疗组、模型组和正常组。动态观察中药补肾活血泄浊汤对肾功能、血液流变学、肾组织β1型转化生长因子（TGF－β1）表达及肾小球基底膜阴离子位点的影响。结果：治疗组各项指标与模型组比较，差异均有显著性，形态学观察也显示治疗组损害轻于模型组。结论：补肾活血泄浊汤具有改善肾功能、缓解血液高凝、高粘状态，保护肾小球阴电荷屏障及延迟肾小球硬化发生的作用。

Experimental Study on Effect of Bushen Huoxue Xiezhuo Decoction in Treating Minimal Change Nephropathy

OBJECTIVE: To explore the therapeutic effect and mechanism of Bushen Huoxue Xiezhuo Decoction (BHXD) in treating minimal change nephropathy (MCN) in rats. METHODS: The MCN model rats established by a single intravenous injection of Adriamycin were divided into the model, BHXD group, and a normal group was set up for control. The effect of treatment on renal function, hemorrheologic parameters, renal tissue TGF-beta 1 expression and polyanion sites on glomerular basement membrane were observed dynamically. RESULTS: After treatment, all the parameters between the BHXD group and the model group were significantly different respectively, morphological observation also showed the pathological changes in the BHXD group were milder than those in the model group. CONCLUSION: BHXD treatment could markedly improve the renal function, alleviate blood hypercoagulability and hyperviscosity, protect the anion barrier and delay the progression of glomerular fibrosis and sclerosis.