脂餐负荷后血清甘油三酯反应水平与颈动脉内中膜厚度的关系

探讨餐后血浆富含甘油三酯脂蛋白蓄积与劝脉粥样硬化的关系。方法４２例经冠状动脉造影证实的男性冠心病患者接受了标准口服脂肪餐负荷试验，分别于餐前及虎后２、４、６、８小时测定血清甘油三酯浓度及空腹血清载脂蛋白Ｂ、高密度脂蛋白胆固浓度。

Postprandial triglyceridemia and carotid atherosclerosis in male patients with coronary heart disease

Objective To test the effect of postprandial accumulation of triglyceride rich lipoprotein(TGRL) on carotid artery atherosclerosis. Methods In 42 male cases with coronary heart disease(CHD) as verified by angiography, high density lipoprotein cholesterol and apolipoprotein B(ApoB) levels in fasting serum , serum triglyceride concentrations before and 2,4,6,8 hours after a standard fat test meal were measured. Each patient underwent a carotid artery high resolution B mode ultrasound examination. The extent of alimentary lipemia area under the triglyceride curve over 8 hours, TG AUC and peak triglyceride response (TGPR)] correlated with the carotid artery intima media thickness. Results Univariate analyses indicated both TG AUC and TGPR had direct correlation with mean intima media thickness measured from four well defined vessel wall segments in the left and right carotid arteries ( r =0.45 and 0.41, both P <0.01). After controlling for age, body mass index(BMI), triglyceride, HDL C, and apolipoprotein B concentrations in fasting serum with multivariate stepwise regression analysis, the above correlation remained. There was an independent inverse correlation between HDL C and carotid artery intima media thickness. Conclusion It is suggested that abnormal metabolism and clearence of postprandial TGRL can promote the progression of atherosclerosis.