阿尔茨海默病不同严重程度时的神经心理学研究

目的 研究阿尔茨海默病（ＡＤ）不同痴呆严重程度时的神经心理模式特点。方法 使用多种神经心理测验测试了符合国际公认的痴呆诊断标准（ＮＩＮＣＤＳ－ＡＤＲＤＡ）“很可能为ＡＤ”的患者,使用临床痴呆评定（ＣＤＲ）确定痴呆严重程度。结果 ＡＤ早期即出现视空间功能障碍,中、重度阶段均明显衰退。认知功能障碍也始于ＡＤ早期,中、重度阶段呈持续性显著衰退趋势,记忆功能在ＡＤ早期即出现大幅度衰退,,中期衰退幅度不大,

Neuropsychological study of dementia severity in Alzheimer's disease

Objective To investigate the neuropsychological pattern of different dementia severity in Alzheimer Disease(AD). Methods Probable AD patients who were examined with NINCDS ADRDA criteria for clinical diagnosis of AD were further examined with several neuropsychological tests and the dementia severity was determined with clinical dementia rating (CDR). Results There was impairement of visuospatial function in mild AD (CDR=1). Evident decline was found in moderatety severe AD (CDR=2) and severe AD (CDR=3).There was impairment of cognition function in mild AD and the decline continued in moderately severe and severe AD. Memory function declined apparently in the early stage of AD, but the decline was not apparent in moderately severe AD. However, the decline became very quick and memory function was completely lost in severe AD. The trend of decline of daily living activity and ability was the same as memory. Alteration in personality appeared in the mild AD and became most evident in severe AD. Conclusion Neuropsychological test is useful in diagnosis of AD in the early stage , and neuropsychological pattern in each stage is useful in differential diagnosis.