卡托普利对急性心肌梗死伴糖尿病患者的疗效观察

目的 观察糖尿病患者发生急性心肌梗死的临床特点及卡托普利对其的近期疗效。方法 本试验共纳入１４６６６例患者,分为糖尿病组和非糖尿病组,其中ＡＭＩ伴糖尿病患者１３７６例,多中心随机双盲安慰剂对照临床试验分为对照临床试验分为对照组７０７例,治疗组６６９例,口服卡托普利或安慰剂,治疗４周。结果 糖尿病ＡＭＩ组４周病死率为１４．７５％,明显高于非糖尿病ＡＭＩ８．８９％。

Clinical effect of captopril in diabetic patients with complicated acute myocardial infarction

Objective To observe the clinical character of the diabetic patients with complicated acute myocardial infarction and to evaluate the earlyterm effect of captopril on these patients. Methods In a multicentre, randomized, double blind and placebocontrolled clinical trial of ACEI for AMI in China. In a total of 14 666 AMI patients 1 376 had diabetes mellitus. The 1 376 diabetic patients with complicated AMI were randomized into captopril(669) and placebo(707). All the patients were treated with captopril(12.5mg three times daily)or placebo for four weeks. Results The results of the entire study showed that the fourweek mortality of AMI showed significant difference between patients with and without diabetes (14.75% vs 8.89%, P<0.0001). The fourweek mortality of AMI in patients with diabetes showed no significant difference between those treated with captopril and placebo (14.95% vs.14.57% P>0.05). Rates of incidence of main complications within four weeks also showed no significant difference between the two groups. Conclusion After AMI, for the patients with diabetes, treatment with captopril not show a beneficial effect on the earlyterm prognosis.