P—选择素在速激肽类致气道高反应性中的作用

目的 探讨黏附分子Ｐ－选择素和速激肽类Ｐ－物质、血管活性肠肽（ＶＩＰ）与气道高反应性的关系。方法 测定５７例支气管哮喘病人（激素治疗组２７例，非激素治疗组３０例）和２２例正常人的气道反应性，观察血浆Ｐ－选择素、Ｐ－物质和ＶＩＰ的变化。结果５３例哮喘病人气道激发试验阳性（９２．９８％），４例阴性（７．０２％），２２例正常人全部阴性。非激素治疗组患者血浆Ｐ－选择素和Ｐ－物质较正常人及激素治疗组显著升

P selectin and tachykinins in bronchial hyperresponsiveness of asthma

Objective The characteristic feature of asthma is bronchial hyperresponsiveness (BHR). It is due predominately to inflammation of airways. Pathologically, there are inflammatory infiltration, epithelial sloughing and mucosal edema in the bronchi. The objective of this study is to investigate the relationship between BHR and airway inflammation. Methods 57 cases of asthma and 22 normal subjects were tested with bronchial reactivity examination and P selectin, substance P (SP) and vasoactive intestinal peptide (VIP) in plasma. Results It was found that the bronchial reactivity to inhaled methacholine was positive in 53 of the 57 asthmatic patients (92 98%), while the remaining four were negative (7.02%). Twenty two normal subjects were all negative with the test of bronchial reactivity. The levels of P selectin and SP in asthmatics with corticosteroids treatment ( n =27) were higher than those in the control group ( P <0.05), but lower than those in asthmatics treated with aminophylline and salbutamol sulfate ( n =30), ( P <0.01). The concentration of VIP in asthmatics with corticosteroids treatment was significantly higher than that of asthmatics with out corticosteroids treatment ( P <0.01) but lower than that in the control group ( P <0.01). There was positive relationship between bronchial reactivity and P selectin ( r =0.328, P <0.05), as well as SP ( r =0.529, P <0.01) in asthmatics, but negative relationship between bronchial reactivity and VIP ( r =-0.419, P <0.05). Conclusion The increase of P selectin and SP and decrease of VIP can induce BHR, corticosteroids can reduce levels of P selectin, SP and enhance the level of VIP, therefore it can improve the reactivity of airway and relieve symptoms.