司帕沙星与氧氟沙星随机对照治疗细菌性感染的临床研究

目的 评价司帕沙星治疗细菌性感染的有效性与安全性。方法 采用多中心随机对照方法，并选用氧氟沙星作为对照。两组共治疗各种感染患者２１２例，其中司帕沙星组１０６例，氧氟沙星组１０６例，均为口服片剂。结果 司帕沙星组与氧氟沙星组痊愈率分别为７４．５％和６９．８％，有效率分别为９１．５％和８８．７％，细菌清除率分别为９０．７％和９０．８％，不良反应发生率分别为９．４３％和８．４９％，以上结果经统计学处理差

A randomized controlled clinical study of sparfloxacin versus ofloxacin in the treatment of bacterial infections

OBJECTIVE: To evaluate the efficacy and safety of sparfloxacin in the treatment of bacterial infections. METHODS: A randomized controlled multi-centre clinical trial was conducted. Ofloxacin used as the control drug. A total of 212 patients entered the study, with 106 in the sparfloxacin group and the remaining 106 in the ofloxacin group. Both compounds were given by oral administration. RESULTS: The cure rate of sparfloxacin and ofloxacin was 74.5% and 69.8% respectively and the overall efficacy rate was 91.5% and 88.7% respectively. The bacterial clearance rate was 90.7% in the sparfloxacin group and 90.8% in the ofloxacin group. The adverse drug reaction rate of sparfloxacin and ofloxacin was 9.43% and 8.49% respectively. There was no statistical significant difference between the two groups for the above results. The results of in vitro activity of sparfloxacin as compared with other 5 antibacterial agents showed that sparfloxacin had good activity against many Gram-negative organisms and was similar to those of ofloxacin. The activity against Gram-positive organisms (MIC(90)