| 肝细胞生长素与肝损伤大鼠雌二醇关系的探讨 |
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| 引用本文： | 陈光明 杨富强. 肝细胞生长素与肝损伤大鼠雌二醇关系的探讨[J]. 解放军医学杂志, 1991, 16(2): 113-116 |
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| 作者姓名： | 陈光明 杨富强 |
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| 作者单位： | 空军广州医院科研室(陈光明，杨富强，张宜俊，孔祥平)，空军广州医院科研室(郑国池) |
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| 摘 要： |
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| 关 键 词： | 肝损伤 雌二醇 肝细胞生长素 |
STUDY ON EFFECT OF HGF ON SERUM ESTRAD1OL LEVEL OF THE RATS WITH LIVER INJURY |
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| Chen Guangming,Yang Fuqiang,Zhang Yijun,Kong Xiangping,Zheng Guochi. Scientific Research Laboratory of Guangzhou Hospital of Air Force,PLA. STUDY ON EFFECT OF HGF ON SERUM ESTRAD1OL LEVEL OF THE RATS WITH LIVER INJURY[J]. Medical Journal of Chinese People's Liberation Army, 1991, 16(2): 113-116 |
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| Authors: | Chen Guangming Yang Fuqiang Zhang Yijun Kong Xiangping Zheng Guochi. Scientific Research Laboratory of Guangzhou Hospital of Air Force PLA |
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| Abstract: | In our laboratory, injection of HGF, prepared by the modified Labrecque's method, was used for the treatment of experimental hepatic injury in rats. It was found that the serum estradiol level was significantly higher in the group of HGF treatment than that in the control group (P<0.01), and the estradiol level, which increased in direct proportion to the dosage of HGF, reached the maximum 4 hours after the HGF injection in various dosages. Such a dynamic state did not appear in HGF treatment group without hepatic injury and in the NS control group. Thus we believe that HGF has a stimulative effect on the hypothalamus or the pituitary gland of the rats with liver injury, which regulates the serum estradiol level by positive feedback, and then hepatocyte regeneration is enhanced. It is our preliminary conclusion that there is a close correlation among liver injury, HGF, estradiol and the liver regeneration, |
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| Keywords: | Liver injury Estradiol HGF |
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