IFITM3基因rs12252位点多态性与中国人群流感易感性:基于研究的序贯Meta分析

  目的  系统评价干扰素诱导跨膜蛋白3（interferon-induced transmembrane protein 3，IFITM3）基因rs12252位点多态性与中国人群流感易感性的定量关系。  方法  检索Medline、PubMed、Embase、Web of Science以及中国知网、万方、维普数据库，收集IFITM3与中国人群流感易感性相关的文章。采用Meta分析方法对收集的文章进行定量地综合分析。  结果  本次研究共纳入7篇文献，共计919例流感感染的病例，涉及到甲型流感（H7N9、H1N1pmd09、H3N2）及乙型流感病毒，序贯Meta分析显示本研究纳入的研究总样本已达到了得到稳定阳性结局所需的样本量。Meta分析结果发现，IFITM3基因的rs12252多态性与中国人群流感病毒易感性存在关联，携带rs12252 C等位基因的人群更易发生流感（C vs T:OR=1.67，95% CI:1.45~1.92；CC vs TT:OR=2.61，95% CI:1.97~3.46；TC vs TT:OR=1.55，95% CI:1.20~2.00；CC vs TC+TT:OR=2.01，95% CI:1.49~2.72；CC+TC vs TT:OR=8.90，95% CI:4.94~16.06）。  结论  IFITM3基因rs12252位点多态性是中国人群发生流感的危险因素。

rs12252 polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis

  Objective  To systematically and quantitatively evaluate the relationship of rs12252 polymorphism in IFITM3 gene and susceptibility to influenza in Chinese population.  Methods  The databases of Medline, PubMed, Embase, Web of Science, China National knowledge infrastructure (CNKI), Wanfang and VIP were searched to retrieve the articles which focused on the topic of relationship between the rs12252 polymorphism and susceptibility to influenza in Chinese population. Meta-analysis method was used to comprehensively and quantitatively analyze the enrolled articles.  Results  Seven papers with a total of 919 influenza cases were involved in this article. Influenza virus involved influenza A (H7N9, H1N1 pmd09, H3N2) and influenza B. Study-based sequential meta-analysis of the study showed that the total sample size of this study have achieved the required sample size to obtain stable positive results. The results of this meta-analysis showed that the rs12252 polymorphism was associated with susceptibility to influenza in Chinese population and that the rs12252C polymorphism in IFITM3 gene was more susceptible to have influenza in Chinese people (C vs T: OR=1.67, 95% CI: 1.45-1.92; CC vs TT: OR=2.61, 95% CI: 1.97-3.46; TC vs TT: OR=1.55, 95% CI: 1.20-2.00; CC vs TC+TT: OR=2.01, 95% CI: 1.49-2.72; CC+TC vs TT: OR=8.90, 95% CI: 4.94-16.06).  Conclusion  the rs12252 polymorphism of IFITM3 gene was a risk factor for influenza in Chinese population.