两种剂量的盐酸羟考酮注射液治疗乳腺癌改良根治术后急性疼痛患者的效果比较

目的:探讨两种剂量的盐酸羟考酮注射液治疗乳腺癌改良根治术后急性疼痛患者的临床效果。方法:选取我院收治的120例择期全麻下行乳腺癌根治术治疗的患者进行研究，按照随机数字表法进行分组，60例患者为对照组，采用低剂量盐酸羟考酮注射液治疗，另60例为观察组，采用高剂量盐酸羟考酮注射液治疗，对比两组患者的镇痛效果、用药不良反应等。结果:两组患者在手术时间、麻醉时间、苏醒时间及拔管时间等指标方面对比均无较大差异性（P＞0.05）；拔除喉罩后5 min、0.5 h、2 h、4 h两组患者在疼痛程度评分方面（VAS）比较均无较大差异性（P＞0.05），但拔除喉罩后8 h、12 h对比，观察组患者VAS评分明显低于对照组（P＜0.05）；两组患者在术后不良事件发生率及镇痛药物追加率方面对比均无较大差异性（P＞0.05），麻醉前，两组患者心率、血压对比均无较大差异（P＞0.05），给药后、苏醒期及恢复期两组各指标均有所变化，但两组间对比均无较大差异性（P＞0.05）。结论:采用高剂量的盐酸羟考酮注射液对乳腺癌改良根治术后急性疼痛患者进行治疗效果显著，能够在改善患者术后急性疼痛程度的同时避免增加术后不良事件，可在临床上推广应用。

Effect of two doses of oxycodone hydrochloride injection on patients with acute pain after modified radical mastectomy for breast cancer

Objective:To investigate the clinical effects of two doses of oxycodone hydrochloride in the treatment of acute pain after modified radical mastectomy for breast cancer.Methods:A total of 120 patients undergoing elective general anesthesia underwent radical mastectomy were enrolled in our hospital.The patients were randomized to a randomized digital table.60 patients were treated with low-dose oxycodone hydrochloride.Sixty patients were treated with high dose oxycodone hydrochloride injection,and the analgesic effect and adverse drug reactions were compared between the two groups.Results:There were no significant differences in the operation time,anesthesia time,wake up time and extubation time between the two groups (P＞0.05).The patients in the two groups were removed 5 min,0.5 h,2 h,4 h after the laryngeal mask was removed.There was no significant difference in pain scores (VAS) (P＞0.05),but the VAS scores of the observation group were significantly lower than those of the control group at 8 h and 12 h after removal of the laryngeal mask (P＜0.05).There was no significant difference in the incidence of postoperative adverse events and the rate of analgesic drugs (P＞0.05).Before anesthesia,there was no significant difference in heart rate and blood pressure between the two groups (P＞0.05).There were changes in the indexes of the two groups after the administration,awakening period and recovery period,but there was no significant difference between the two groups (P＞0.05).Conclusion:High-dose oxycodone hydrochloride injection is effective in the treatment of patients with acute pain after modified radical mastectomy.It can improve the postoperative acute pain level and avoid the increase of postoperative adverse events.It can be promoted clinically application.