中医体质类型与子宫肌瘤相关性的Meta分析

目的 通过对子宫肌瘤人群与中医体质相关性的临床研究进行Meta分析，探究中医体质类型在子宫肌瘤及非子宫肌瘤人群中的分布差异，以期为临床与科研提供基于较大样本的较高级别的循证医学证据。 方法 分别检索从中国生物医学文献数据库(CBMdisc)、中国知网数据库(CNKI)、万方数据库(Wanfang database)、重庆维普中文科技期刊数据库(VIP)、PubMed及Embase数据库建库至2017年5月31日的相关文献，对纳入研究的文献采用Review Manager5.2软件进行Meta分析。 结果 共纳入2012—2015年的6项研究2 193例研究对象。Meta分析结果显示:平和质(OR=0.13，95%CI为0.04~0.36)是子宫肌瘤的保护性因素(P<0.05)，痰湿质(OR=1.67，95%CI为1.23~2.28)、气郁质(OR=1.97，95%CI为1.48~2.64)和血瘀质(OR=4.56，95%CI为2.54~8.19)是子宫肌瘤的危险因素(均P<0.05)，气虚质、阳虚质、阴虚质和湿热质与子宫肌瘤无明显相关性(均P>0.05)。 结论 本研究为子宫肌瘤的中医药防治提供了一定的循证医学证据。但鉴于纳入研究多为中等质量研究，期待更多高质量、多中心、大样本的研究提供更高级别的循证医学证据。 

Correlation between TCM constitution and Hysteromyoma:a meta-analysis

Objective To explore the difference between the distribution of traditional Chinese medicine (TCM) constitution of hysteromyoma and non-hysteromyoma population through the meta-analysis of the clinical studies on the correlation between hysteromyoma and TCM constitution, in order to provide higher level evidence based on larger sample for clinical and scientific research. Methods Literatures of CBMdisc, CNKI, Wanfang database, VIP, PubMed and Embase database from the database creation to May 31,2017 were searched, and Meta-analysis was performed by Review Manager 5.2 software. Results Totally 6 studies from 2012-2015 were included with 2 193 individuals. The results showed that balanced constitution (OR=0.13, 95% CI 0.04-0.36)was a protective factor of hysteromyoma (P<0.05) while phlegm-dampness (OR=1.67, 95% CI 1.23-2.28), qi stagnation(OR=1.97, 95% CI 1.48-2.64)and blood stasis constitutions(OR=4.56, 95%CI 2.54-8.19)were risk factors of hysteromyoma (all P<0.05), and there were no obvious correlations among qi deficiency, yang deficiency, yin deficiency, damp-heat constitutions and hysteromyoma (all P>0.05). Conclusion This study provides evidence for the prevention and treatment of hysteromyoma in TCM. However, most of the included studies are moderate quality, more high-quality, multi-center, large-sample studies are expected to provide higher level evidence.