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脂肪干细胞对乳腺癌生物学特性影响的研究进展
引用本文:万言,梁至洁,韦长元. 脂肪干细胞对乳腺癌生物学特性影响的研究进展[J]. 肿瘤防治研究, 2019, 46(10): 951-955. DOI: 10.3971/j.issn.1000-8578.2019.19.0429
作者姓名:万言  梁至洁  韦长元
作者单位:1. 530021 南宁,广西医科大学附属肿瘤医院乳腺外科;2. 530022 南宁,广西医科大学第五附属医院乳腺中心
摘    要:干细胞辅助移植技术已广泛应用于体表软组织缺陷整形,在乳腺癌术后重建中的应用成为未来的趋势,其中脂肪干细胞(ADSCs)具有良好的增殖、多向分化以及旁分泌等功能,能优化自体脂肪移植疗效,但其在体外对乳腺癌细胞的增殖、上皮间质化以及乳腺癌新生血管形成都有促进作用,在肿瘤学安全性上存在质疑。本文旨在概述ADSCs在乳房重建中的潜在作用,讨论其对乳腺肿瘤学安全性的影响。

关 键 词:脂肪干细胞  乳腺癌  术后重建  肿瘤学安全性  
收稿时间:2019-04-02

Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer
WAN Yan,LIANG Zhijie,WEI Changyuan. Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2019, 46(10): 951-955. DOI: 10.3971/j.issn.1000-8578.2019.19.0429
Authors:WAN Yan  LIANG Zhijie  WEI Changyuan
Affiliation:1. Department of Breast Surgery, Guangxi Medical University Affiliated Tumor Hospital, Nanning 530021, China; 2. Breast Surgery Center, Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530022, China
Abstract:Stem cell-assisted transplantation technology has been widely used in superficial soft tissue defect remodeling, and has been the trend of the future in postoperative reconstruction of breast cancer. Adiposederived stem cells(ADSCs) possess excellent abilities of proliferation, multi-differentiation, paracrine and so on, and they are very important in efficacy optimization of autologous fat grafting. However, ADSCs have been proved to promote the proliferation, epithelialization of breast cancer cells and the formation of new blood vessels in breast cancer in vitro, arousing a controversy about oncology safety. This review aims to outline the potential role of ADSCs in breast reconstruction and discuss their safety impact on breast cancer.
Keywords:Adipose-derived stem cells  Breast cancer  Postoperative reconstruction  Oncology safety  
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