| DNA甲基化基因DNMT1的研究进展 |
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| 引用本文： | 黄 滔1,' target='_blank'>2,周兴路2,' target='_blank'>3,毛曦轲2,' target='_blank'>4,苏天宇1,' target='_blank'>2,陈晨晨1,' target='_blank'>2,吴志浩2,' target='_blank'>5. DNA甲基化基因DNMT1的研究进展[J]. 现代肿瘤医学, 2019, 0(14): 2595-2600. DOI: 10.3969/j.issn.1672-4992.2019.14.040 |
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| 作者姓名： | 黄 滔1 ' target='_blank'>2 周兴路2 ' target='_blank'>3 毛曦轲2 ' target='_blank'>4 苏天宇1 ' target='_blank'>2 陈晨晨1 ' target='_blank'>2 吴志浩2 ' target='_blank'>5 |
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| 作者单位： | 1.皖南医学院临床医学院；2.肿瘤微环境研究室；3.检验学院；4.麻醉学院；5.基础医学院，安徽 芜湖 241002 |
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| 基金项目： | National Natural Science Foundation of China(No.81872371）；国家自然科学基金（编号:81872371）；国家级大学生创新创业训练计划项目（编号:201710368008）；安徽省自然科学基金（编号:1708085MH203）；安徽省高等教育振兴计划思想政治教育综合改革计划弘扬核心价值观名师工作室项目（编号:Szzgjh1-2-2018-12） |
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| 摘 要： | DNA甲基转移酶1(DNMT1)是哺乳动物基因组表观遗传修饰中DNA甲基化的关键基因，其编码的蛋白是一种分子量大且功能复杂的酶，具有多种调控功能，参与机体发育过程中干细胞生长、细胞增殖、器官发育、衰老和肿瘤发生等多个生物学过程。本文将对DNMT1基因的结构与分子作用机制进行介绍，并总结其表达调控、生物学功能及其与肿瘤等人类疾病相关的研究进展。
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| 关 键 词： | DNMT1 DNA甲基化 表达调控 肿瘤 |
Advances in research on DNA methylation gene DNMT1 |
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| Huang Tao1,' target='_blank'>2,Zhou Xinglu2,' target='_blank'>3,Mao Xike2,' target='_blank'>4,Su Tianyu1,' target='_blank'>2,Chen Chenchen1,' target='_blank'>2,Wu Zhihao2,' target='_blank'>5. Advances in research on DNA methylation gene DNMT1[J]. Journal of Modern Oncology, 2019, 0(14): 2595-2600. DOI: 10.3969/j.issn.1672-4992.2019.14.040 |
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| Authors: | Huang Tao1 ' target='_blank'>2 Zhou Xinglu2 ' target='_blank'>3 Mao Xike2 ' target='_blank'>4 Su Tianyu1 ' target='_blank'>2 Chen Chenchen1 ' target='_blank'>2 Wu Zhihao2 ' target='_blank'>5 |
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| Affiliation: | 1.School of Clinical Medicine;2.Tumor Microenvironment Research Laboratory;3.School of Laboratory Medicine;4.School of Anesthesia;5.School of Basic Medicine,Wannan Medical College，Anhui Wuhu 241002，China. |
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| Abstract: | DNA methyltransferase 1 (DNMT1) is a key gene for DNA methylation in epigenetic modification of mammalian genomes.It's encoded protein is a large molecular weight and complex enzyme,and it is involved in many biological processes such as stem cell growth,cell proliferation,organ development,aging and tumorigenesis during body development.This article will introduce the structure and molecular mechanism of DNMT1 gene，and summarize its research progress on expression regulation,biological function and its relationship with tumor and other human diseases. |
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| Keywords: | DNMT1 DNA methylation expression regulation tumor |
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