浆母细胞淋巴瘤1例报告及文献回顾

目的:探讨浆母细胞淋巴瘤（plasmablastic lymphoma，PBL）的临床病理特征及预后。方法:对1例鼻腔浆母细胞淋巴瘤进行光镜、免疫组化及原位杂交检测，并回顾分析63例文献报告病例。结果:肿瘤组织由中等或大细胞弥漫增生组成，胞浆少，嗜碱性，部分细胞胞浆嗜酸性伴核偏位，核圆形或卵圆形，核仁较明显，核分裂象易见，可见凋亡及肿瘤性坏死；免疫组化:瘤细胞CD79a、CD138、Plasma cell弥漫强（+），Ki-67（约90%+），LCA、CD20（-）；原位杂交:EBER（-）。结论:PBL在诊断标准、鉴别诊断及治疗方面仍存在争议，尚需积累更多病例进一步探讨。

Plasmablastic lymphoma:Report of one case and review of literature

Objective:To investigate the clinicopathological features and prognosis of plasmablastic lymphoma (PBL).Methods:One case of nasal plasmablastic lymphoma was examined by light microscopy，immunohistochemistry and in situ hybridization，and 63 cases reported in the literature were retrospectively analyzed.Results:Tumor tissue consisted of moderate or large cell diffuse hyperplasia，with little cytoplasm，basophilic，partial cytoplasmic eosinophilic with nuclear deviation， round or oval nucleus，obvious nucleoli obvious.Mitotic figures were easy to see.Apoptosis and neoplastic necrosis were visible.Immunohistochemistry showed tumor cells CD79a，CD138，plasma cell diffuse strong (+)，Ki-67 (about 90%+)，LCA，CD20 (-)，and in situ hybridization with EBER(-).Conclusion:PBL is still controversial in terms of diagnostic criteria，differential diagnosis and treatment，and more cases need to be accumulated to further explore.