| 长链非编码RNA在糖尿病视网膜病变发展及治疗中的研究进展 |
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| 引用本文： | 郎海波,黄敏丽.长链非编码RNA在糖尿病视网膜病变发展及治疗中的研究进展[J].眼科新进展,2019,0(5):482-485. |
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| 作者姓名： | 郎海波 黄敏丽 |
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| 作者单位： | 530000 广西壮族自治区南宁市，广西医科大学第一附属医院眼科 |
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| 基金项目： | 广西自然科学基金资助(编号:2014GXNSFAA118273);广西教育厅高校科研项目(编号:YB2014072)~~ |
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| 摘 要： | DR是世界各地工作年龄段成年人失明的主要原因,其发病机制是多因素的,分子机制尚不完全清楚。长链非编码RNA(lncRNAs)被认为是多细胞功能的关键调节因子,已有证据表明其参与了DR的许多病理生理机制,本文就lncRNAs在DR中发挥功能的分子机制及调控作用进行综述,为今后DR的防治研究提供一定的策略和方向。
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| 关 键 词： | 长链非编码RNA 糖尿病视网膜病变 分子调控机制 |
Research progress of lncRNA in the development and treatment of diabetic retinopathy |
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| LANG Hai-Bo,HUANG Min-Li.Research progress of lncRNA in the development and treatment of diabetic retinopathy[J].Recent Advances in Ophthalmology,2019,0(5):482-485. |
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| Authors: | LANG Hai-Bo HUANG Min-Li |
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| Institution: | Department of Ophthalmology，First Affiliated Hospital of Guangxi Medical University，Nanning 530000，Guangxi Zhuang Autonomous Region，China |
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| Abstract: | Diabetic retinopathy （DR） is the main cause of adult blindness in working-age adults around the world.Its pathogenesis is multifactorial and the molecular mechanism is not yet fully understood.Long non-coding RNAs （lncRNAs） are considered to be the major regulators of multicellular function.There is evidence that they are involved in many pathophysiological mechanisms of DR.This article reviews the molecular mechanisms and regulation of lncRNAs functioning in DR to provide a positive strategy and direction for future DR studies. |
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| Keywords: | long non-coding RNA diabetic retinopathy molecular regulation mechanism |
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