基于TCGA数据库的AIM2在结直肠癌中的表达分析及临床相关性研究

目的:通过独立公开的TCGA数据库资源,探讨黑色素瘤缺乏因子2(AIM2)的表达与结直肠癌患者临床病理特征的相关性。方法:TCGA数据平台(https://portal.gdc.cancer.gov/)下载结直肠癌组织和正常组织AIM2基因表达数据及相关临床数据,并分析其表达与临床病理特征的关系。结果:癌组织中AIM2的表达显著低于正常对照组(P=0.0013),且正常对照组中AIM2的表达显著高于任何T分期、任何N分期以及任何M分期患者的癌组织(P<0.0001);癌组织中AIM2的表达与患者年龄、性别、肿瘤位置、T分期、N分期、M分期和病理分期均无明显相关(P>0.05),与患者5年总生存期无明显相关(P=0.4180);Ⅱ期患者癌组织中AIM2的表达显著高于IV期患者(P=0.0237)。结论:结直肠癌组织中AIM2的表达显著低于正常组织,但与患者T分期、N分期、M分期和患者5年总生存期无明显相关,Ⅱ期患者癌组织中AIM2的表达显著高于IV期患者,因此,AIM2的表达可能主要参与结直肠癌发生的早期过程。该结论仍需通过更多的研究进行验证。

Association between AIM2 expression and clinicopathological variables in colorectal cancer:Research based on TCGA data

Objective:To investigate the association between absent in melanoma 2 (AIM2) expression and clinicopathological variables in colorectal cancer (CRC) based on TCGA data.Methods:Data about AIM2 gene expression in CRC was downloaded from TCGA platform (https://portal.gdc.cancer.gov/).Correlation between AIM2 expression and clinicopathological variables was analyzed.Results:Expression level of AIM2 in CRC was significantly lower than in normal control (P=0.001 3)，also higher expression of AIM2 was observed in normal control than in cancer cases with any T stage，N stage and M stage(P<0.000 1).AIM2 expression had no correlation with gender，age，tumor location，T stage，N stage，M stage,pathological stage and 5-year overall survival rates (5-OS)，but higher expression of AIM2 was observed in stage II than in stage IV (P=0.023 7).Conclusion:The expression level of AIM2 in cancer cases is lower than in normal control，but has no relation with clinicopathological variables and 5-OS in CRC，but the expression level of AIM2 is higher in stage II than in stage IV.So，the expression of AIM2 might be involved in the early course of colorectal cancer.Further studies are warranted to confirm this conclusion.