| 肿瘤中SWI/SNF复合物亚基变异的作用及其相关治疗策略进展 |
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| 引用本文： | 郭庆,饶秋,周志毅. 肿瘤中SWI/SNF复合物亚基变异的作用及其相关治疗策略进展[J]. 肿瘤防治研究, 2019, 46(7): 644-649. DOI: 10.3971/j.issn.1000-8578.2019.18.1871 |
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| 作者姓名： | 郭庆 饶秋 周志毅 |
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| 作者单位： | 1. 214023 无锡，南京医科大学附属无锡人民医院病理科；2. 210002 南京，解放军南京总医院病理科 |
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| 摘 要： | SWI/SNF复合物是调节真核细胞基因表达的一种重要而复杂的多亚基蛋白复合物,广泛参与信号转导、细胞周期及分化等各种生物过程,其亚基基因在20%以上的恶性肿瘤中发生突变。本文综述了该复合物及其亚基在恶性肿瘤中的作用和特征,并探讨SWI/SNF复合物在肿瘤治疗中的潜在临床应用。
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| 关 键 词： | 恶性肿瘤 SWI/SNF复合物 致癌机制 治疗策略 |
| 收稿时间： | 2018-12-07 |
Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of RelatedTherapeutic Strategies |
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| GUO Qing,RAO Qiu,ZHOU Zhiyi. Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of RelatedTherapeutic Strategies[J]. Cancer Research on Prevention and Treatment, 2019, 46(7): 644-649. DOI: 10.3971/j.issn.1000-8578.2019.18.1871 |
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| Authors: | GUO Qing RAO Qiu ZHOU Zhiyi |
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| Affiliation: | 1. Department of Pathology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China; 2. Department of Pathology, Nanjing General Hospital of PLA, Nanjing 210002, China |
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| Abstract: | The SWI/SNF complex is an important multi-subunit protein complex that regulates gene expression in eukaryotic cells. It is widely involved in various biological processes such as signal transduction, cell cycle and cell differentiation. SWI/SNF complex subunit mutations occur in more than 20% of malignant tumors. This article reviews the role and characteristics of this complex and its subunits in malignant tumors, and explores the potential clinical application of SWI/SNF complexes in tumor therapy. |
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| Keywords: | Malignant tumor SWI/SNF complex Carcinogenic mechanism Treatment strategy |
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