华东地区成人高血压人群中空腹血糖水平与臂踝脉搏波传导速度的关联性

目的探讨华东地区农村高血压人群空腹血糖水平与臂踝脉搏波传导速度(branchial-ankle pulse wave velocity,baPWV)的关联性.方法 2013年7月~9月在连云港市的赣榆县和东海县、安庆市的枞阳和望江县开展关于高血压患者合并相关危险因素的横断面研究.以空腹血糖水平作为自变量,以baPWV作为因变量进行多元线性回归分析.结果本研究共纳入共3 894例高血压患者,其中血糖正常(normal fasting glucose,NFG)、空腹血糖受损(impaired fastingglucose,IFG)以及糖尿病(diabetes mellitus,DM)的人群分别占44.5%、43.0%和12.5%.分析显示,baPWV与空腹血糖水平存在关联,且空腹血糖水平每增加1 mmol/L,baPWV水平随之升高26.2 cm/s(95% CI:19.6~32.8,P<0.001).与NFG人群相比,IFG(β=50.4 cm/s,95% CI:28.4 ~ 72.3,P<0.001)和DM(β=113.4 cm/s,95% CI:80.2 ~ 146.5,P<0.001)人群baPWV水平均呈升高.另外,空腹血糖与baPWV水平在收缩压≥140 mmHg的人群中具有更强的关联(β=34.3 cm/s,95% CI:24.5~44.2,P<0.001 vs.收缩压<140 mmHg;β=18.1 cm/s,95% CI:9.1~27.2,P<0.001;交互P=0.027).结论华东地区农村高血压人群中,空腹血糖水平与baP-WV水平呈正相关.

Association between fasting glucose and branchial-ankle pulse wave velocity among hypertensive population in rural areas of Eastern China

  Objective  To explore the relationship between fasting blood glucose and branchial-ankle pulse wave velocity (baPWV) levels among hypertensive population in rural areas of Eastern China.  Methods  A cross-sectional analysis were conducted among hypertensive population in Lianyungang and Anqing city from July to September 2013. Multivariable linear regression models were used to analyze the association of serum glucose and baPWV.  Results  A total of 3 894 hypertensive participants were included in the present study. The prevalence of normal fasting glucose (NFG), impaired fasting glucose (IFG) and diagnosed diabetes (DM) were 44.5%, 43.0%, and 12.5%, respectively. Each 1-mmol/L increase in fasting blood glucose levels was significantly associated with a 26.2 cm/s increase in baPWV levels (95% CI: 19.6-32.8, P < 0.001). Consistently, significantly higher baPWV levels were observed in participants with IFG (β=50.4 cm/s, 95% CI: 28.4-72.3, P < 0.001) and DM (β=113.4 cm/s, 95% CI: 80.2-146.5, P < 0.001) when compared to those with NFG. Furthermore, a stronger positive association between fasting blood glucose and baPWV was observed in participants with systolic blood pressure (SBP) ≥ 140 mmHg (β=34.3 cm/s, 95% CI: 24.5-44.2, P < 0.001; vs. < 140 mmHg; β=18.1 cm/s, 95% CI: 9.1-27.2, P < 0.001; P_interaction=0.027).  Conclusion  There was a positive association between fasting blood glucose and baPWV levels among hypertensive population in rural areas of Eastern China.