Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2 |
| |
Authors: | Teng Liu Juan Xu Hong Li Yan Feng Chun Cheng Xi Jie Liu |
| |
Affiliation: | * Department of Pediatric Surgery, Binzhou Medical University Hospital, Binzhou City, Shandong Province, P.R. China† Pediatric Respiration and Intensive Care Unit, Binzhou Medical University Hospital, Shandong Province, P.R. China‡ Electrocardiogram Room, Binzhou Medical University Hospital, Binzhou City, Shandong Province, P.R. China |
| |
Abstract: | Luteolin, which is found in plant foods, has a range of therapeutic applications. In order to examine the potential roles of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was selected for functional experiments in vitro and in vivo. We demonstrated that luteolin inhibited the proliferation and colony formation of PA-1 cells in vitro. The flow cytometry results suggested that luteolin induced apoptosis of PA-1 cells in a dose-dependent manner. Immunofluorescence and qRT-PCR results showed that the expression of B-cell lymphoma-2 (Bcl-2) was decreased in luteolin-treated cells, whereas the expression of Bcl-2-associated X (Bax) was increased compared with that in the control group. In addition, luteolin inhibited the tumor growth of ovarian teratocarcinoma cells in a xenograft model. All the results suggested that luteolin induced cell apoptosis and inhibited tumor growth of PA-1 cells. |
| |
Keywords: | Luteolin PA-1 Apoptosis Bcl-2 |
|
| 点击此处可从《Oncology research》浏览原始摘要信息 |
|
点击此处可从《Oncology research》下载全文 |
|