| 细胞焦亡在眼部疾病中的研究进展 |
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| 引用本文： | 张敏,李志坚,王亚敏. 细胞焦亡在眼部疾病中的研究进展[J]. 眼科新进展, 2019, 0(1): 082-85. DOI: 10.13389/j.cnki.rao.2019.0019 |
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| 作者姓名： | 张敏 李志坚 王亚敏 |
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| 作者单位： | 150001 黑龙江省哈尔滨市，哈尔滨医科大学附属第一医院眼科医院 |
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| 摘 要： | 细胞焦亡与细胞凋亡、细胞坏死及自噬不同，是一种程序性促炎性细胞死亡方式。其主要信号通路包括依赖caspase-1的经典焦亡途径和依赖caspase-4/5、caspase-11的非经典焦亡途径。已有大量研究表明，细胞焦亡与感染性疾病、动脉粥样硬化性疾病、代谢性疾病及重要脏器非细菌性炎性疾病相关。近几年细胞焦亡在眼部疾病中也有部分研究，包括老年性黄斑变性、角膜炎、白内障等疾病。本文主要综述细胞焦亡的主要机制及其在眼部疾病中的研究进展。
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| 关 键 词： | 细胞焦亡 老年性黄斑变性 角膜炎 白内障 |
Research progress of pyroptosis in ocular diseases |
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| ZHANG Min,LI Zhi-Jian,WANG Ya-Min. Research progress of pyroptosis in ocular diseases[J]. Recent Advances in Ophthalmology, 2019, 0(1): 082-85. DOI: 10.13389/j.cnki.rao.2019.0019 |
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| Authors: | ZHANG Min LI Zhi-Jian WANG Ya-Min |
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| Affiliation: | Eye Hospital，the First Affiliated Hospital of Harbin Medical University，Harbin 150001，Heilongjiang Province，China |
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| Abstract: | Pyroptosis is a programmed pro-inflammatory cell death mode which different from apoptosis，necrosis and autophagy.The main signaling pathways include classic caspase-1-dependent pyroptosis and non-classical caspase-4/5-dependent and caspase-11 dependent pyroptosis.A large number of studies have shown that pyroptosis is associated with infectious diseases，atherosclerotic diseases，metabolic diseases and important non-bacterial inflammatory diseases of organs.In recent years，pyroptosis has been studied in some eye disease，including age-related macular degeneration，keratitis，cataract and other diseases.The main mechanism of pyroptosis and its progress in ocular diseases will be reviewed in this paper. |
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| Keywords: | pyroptosis age-related macular degeneration keratitis cataract |
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