康柏西普对糖尿病黄斑水肿患者黄斑区视网膜微循环的作用:基于光学相干断层扫描血管成像（OCTA）的评价

目的　应用光学相干断层扫描血管成像（OCTA）评价康柏西普对糖尿病黄斑水肿患者黄斑区视网膜微循环的影响。方法　回顾性分析17例（20眼）糖尿病黄斑水肿患者资料，所有患者均行玻璃体内注射康柏西普治疗。分析比较术前和术后1个月患者最佳矫正视力、视网膜中央厚度和OCTA测得的视网膜各参数。结果　所有患者抗VEGF治疗后随访1个月，效果良好；最佳矫正视力(logMAR)从术前的 0.66±0.23提高到0.50±0.26；视网膜中央厚度从术前的（497.2±71.6）μm降至（341.3±54.2）μm，差异均有统计学意义（均为P<0.05）。OCTA测量的无血管区面积和各毛细血管层的黄斑区血管密度等参数在抗VEGF治疗前后差异均无统计学意义（均为 P>0.05）。结论　玻璃体内注射康柏西普能够有效减轻黄斑水肿、提高视力，且不会加剧黄斑区无灌注程度，不会加重黄斑区微循环障碍。

Analysis of the macular retinal microcirculation after intravitreal injection of Conbercept in eyes with diabetic macular edema based on optical coherence tomography angiography

Objective　To observe the clinical therapeutic efficacy of a single intravitreal injection of Conbercept for diabetic macular edema，and to evaluate the macular perfusion status using optical coherence tomography angiography （OCTA）.Methods　A retrospective study was conducted in 17 patients （20 eyes） and the clinical data were reviewed and analyzed.All patients received the intravitreal injection of Conbercept，and underwent best-corrected visual acuity （BCVA），central retinal thickness and OCTA measurements before and one month after intravitreal injection.Results　The study evaluated 20 eyes of 17 patients with diabetic macular edema ［mean (67.2±11.6)years old］.At 1 month after injection，the logarithm of minimum angle of resolution （logMAR） BCVA significantly improved from (0.66±0.23)logMAR to (0.50±0.26)logMAR （P<0.05），and the average central retinal thickness decreased significantly from (497.2±71.6)μm to (341.3±54.2)μm （P<0.05）.No significant difference was found with respect to the foveal avascular zone area and vessel density in the fovea and parafovea （all P>0.05）.Conclusion　This study demonstrated that intravitreal injection of Conbercept can alleviate the diabetic macular edema and restore the visual acuity.The foveal avascular zone area and vessel density remained stable after a single intravitreal anti-VEGF injection.