精索静脉曲张性不育与中医体质的相关性研究

目的探讨精索静脉曲张性不育患者中医体质辨识的分布规律并分析其精液参数与中医体质之间的相关性。方法选取2016年9月1日—2017年11月30日期间在宁波市中医院男科门诊就诊并符合纳入标准的患者146例,年龄20～45岁。通过回收患者所填写的《精索静脉曲张性不育临床症状调查表》、《中医体质观察表》,记录患者一般信息、精液常规以及中医体质情况等结果,再经过相关统计学处理,分析患者基本信息、中医体质及精液常规相关结果之间的统计学关系。结果 (1)146例精索静脉曲张性不育患者中,各体质类型所占比例分别为气郁质17.59%、气虚质16.67%、血瘀质11.58%、阴虚质11.34%、阳虚质10.88%、痰湿质9.72%、湿热质9.49%、平和质7.87%、特禀质4.86%。(2)在相关精液参数与主要中医体质类型的关系中,采用非参数秩和检验或者独立样本t检验分析后可知,气郁质与非气郁质、阴虚质与非阴虚质患者的精子浓度差异均有统计学意义(均P<0.05),气虚质与非气虚质患者的精子总活力差异有统计学意义(P<0.05)。而前向运动精子及正常形态精子比例与主要中医体质类型之间不相关(均P>0.05)。结论精索静脉曲张性不育与中医体质类型相关;其精子浓度分别与气郁质、阴虚质有相关性,精子总活力与气虚质有相关性。

Relationship between male infertility caused by varicocele and body constitution in TCM

Objective To explore the distribution rule of TCM constitution identification in patients with varicocele infertility, and analyze the correlation between the parameters of related semen and TCM constitution. Methods Total 146 patients meeting the inclusion criteria of male infertility caused by varicocele, aged 20 to 45 years, from the andrology clinic in Ningbo Hospital of TCM from September 2016 until November 2017 were enrolled into study. The general information, semen analysis and body constitution in TCM were collected by "Questionnaire of Clinical Symptoms of Male Infertility Caused by Varicocele" and "Scale for Body Constitution in TCM", and their relationships were analyzed by using statistical methods. Results ①Among the 146 cases, qi-stagnation constitution accounted for 17.59%, qi-deficiency constitution for 16.67%, blood-stasis constitution for 11.57%, yin-deficiency constitution for 11.34%, yang-deficiency constitution for 10.88%, phlegm-dampness constitution for 9.72%, damp-heat constitution for 9.49%, gentleness constitution for 7.87%, and special-innateness constitution for 4.86%. ②There was statistically difference in the sperm concentration between qi-deficiency constitution and non qi-deficiency constitution patients and between yin-deficiency constitution and non yin-deficiency constitution patients by using the nonparametric rank sum test or t-test for independent samples (all P<0.05). However, there is no statistical significance between the main TCM constitution and the rate of forward moving sperm and normal morphological sperm (all P>0.05). Conclusion Varicocele infertility is related to TCM constitution.The sperm concentration is respectively correlated with qi-stagnation constitution and yin-deficiency constitution, and the total sperm motility is correlated with qi-deficiency constitution.