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A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests |
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| Authors: | Caoimhe Nic Fhogartaigh David A. B. Dance Viengmon Davong Pisey Tann Rattanaphone Phetsouvanh Paul Turner Sabine Dittrich Paul N. Newton |
| Affiliation: | aLao—Oxford—Mahosot Hospital—Wellcome Trust Research Unit, Microbiology Laboratory, Vientiane, Lao PDR;bPublic Health England, London, England, United Kingdom;cCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Old Road Campus, University of Oxford, Oxford, England;dCambodia—Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia |
| Abstract: | Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings. |
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