术前NLR、PLR、SII与甲状腺乳头状癌临床病理特征的关系

目的 研究外周血中性粒细胞和淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板和淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)及系统性免疫性炎症指数(systemic immune-inflammation index,SII)与甲状腺乳头状癌临床病理特征的关系。 方法 回顾性分析2015年1月—2017年12月在中国人民武装警察部队特色医学中心甲状腺和乳腺外科初次行手术治疗的甲状腺乳头状癌患者临床病理资料，分别讨论NLR、PLR、SII与甲状腺乳头状癌患者临床病理特征的关系。 结果 术前NLR与甲状腺乳头状癌的双侧癌(P=0.040)和多灶性有关(P<0.001)，与患者年龄、性别、肿瘤直径、TNM分期及腺外侵犯、颈部淋巴结转移无关(均P>0.05);术前PLR与患者性别(P=0.019)、颈部淋巴结转移有关(P=0.048)，与年龄、肿瘤直径、TNM分期、多灶性、双侧癌和腺外侵犯无关(均P>0.05)；术前SII与甲状腺乳头状癌的多灶性(P<0.001)和双侧癌(P=0.002)有关,与患者年龄、性别、肿瘤直径、TNM分期以及腺外侵犯、颈部淋巴结转移无关(均P>0.05)。 结论 术前外周血NLR、PLR、SII水平可反映甲状腺乳头状癌的生物学特征，较高的NLR、PLR、SII值与较差的病理组织学特征和更加侵袭性的临床生物学行为密切相关。 

Association of the preoperative NLR,PLR and SII with clinicopathological characteristics in patients with papillary thyroid cancer

Objective To investigate the correlation of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) with clinicopathological characteristics in patients with papillary thyroid cancer. Methods A retrospective study was performed to analyze the clinical data of patients with thyroid papillary carcinoma who accepted surgery treatment firstly in the Affiliated Hospital of Logistics University of PAP from January 2015 to December 2017. The relationship between NLR, PLR and SII and clinicopathological characteristics of papillary thyroid carcinoma was discussed. Results The preoperative NLR significantly correlated with bilateral carcinoma (P=0.040) and multifocality (P<0.001) in papillary thyroid cancer, but not with the age, sex, tumor size, TNM staging, extrathyroidal invasion and cervical lymph node metastasis (all P>0.05). The preoperative PLR obviously correlated with the sex (P=0.019) and cervical lymph node metastasis (P=0.048) in papillary thyroid cancer, but not with the age, tumor size, TNM staging, multifocality, Bilateral carcinoma, and extrathyroidal invasion (all P>0.05). The preoperative SII correlated with multifocality (P<0.001) and bilateral carcinoma (P=0.002) in papillary thyroid cancer, but not with the age, sex, tumor size, TNM staging, extrathyroidal invasion, and cervical lymph node metastasis in papillary thyroid cancer (all P>0.05). Conclusion The preoperative levels of NLR, PLR and SII can reflect the biological characteristics of papillary thyroid carcinoma. The increased NLR, PLR and SII levels in papillary carcinomas might correlate with the poorer histopathological profile and more aggressive clinical behavior.