三维适形放疗联合化疗对中晚期食管癌患者预后的影响

目的:分析三维适形放疗（three-dimensional conformal radiotherapy，3D-CRT）联合奈达铂+多烯紫杉醇同步放化疗对中晚期食管癌患者预后的影响。方法:将本院2016年3月至2017年3月收治的80例中晚期食管癌患者作为研究对象，对照组给予3D-CRT治疗，试验组在对照组治疗基础上给予奈达铂+多烯紫杉醇进行同步放化疗，两组各40例。比较两组患者临床疗效、不良反应及随访1年的生存状况。结果:试验组近期临床有效率为87.50%，较对照组的50.00%显著升高（P<0.01）；两组不良反应发生率如恶心呕吐、食欲下降、肾功能损害的比较，存在明显差异（P<0.05）；随访1年，两组患者均无失访病例，其中试验组1年生存率为92.50%，较对照组的52.50%显著升高（P<0.01）。结论:相比单一3D-CRT，3D-CRT联合奈达铂+多烯紫杉醇同步放化疗可有效提高食管癌患者近远期临床疗效，不会加重远期不良反应，可有效延长患者生存时间，因此具有良好的临床应用价值。

The effect of three-dimensional conformal radiotherapy combined with chemotherapy on the prognosis of patients with middle and advanced esophageal cancer

Objective:To analyze the effect of three-dimensional conformal radiotherapy(3D-CRT) combined with nedaplatin+paclitaxel as concurrent chemoradiotherapy on the prognosis of patients with middle and advanced esophageal cancer.Methods:80 patients with middle and advanced esophageal cancer in our hospital from March 2016 to March 2017 were selected as the object of study，and control group receiving 3D-CRT treatment，and the experiment group receicvmg nedaplatin+docetaxel as concurrent chemotherapy on the basis of the control group，with 40 cases in each group.The clinical efficacy，adverse reaction and 1-year survival of the two groups were compared.Results:The short-term clinical efficiency of the experiment group was 87.50%，which was significantly higher than in the control group of 50.00%(P<0.01).Adverse reactions of two group such as nausea，vomiting，loss of appetite，impairment of renal function showed significant difference(P<0.05).After 1 years of follow-up，two groups showed no lost cases.The 1-year survival rate in the experiment group was 92.50%，which was significantly higher than in the control group of 52.50%(P<0.01).Conclusion:Compared with single 3D-CRT，3D-CRT combined with nedaplatin+docetaxel as concurrent chemotherapy can effectively improve the long-term clinical effect in patients with esophageal cancer，and it does not aggravate the long-term adverse reactions，which can effectively prolong the survival time，so it has good clinical application value.