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High dose rate brachytherapy for prostate cancer: Standard of care and future direction
Institution:1. Department of Radiation Biology, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausseen 70, 0379 Oslo, Norway;2. Department of Core Facilities, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausseen 70, 0379 Oslo, Norway;3. Norwegian Computing Center, Gaustadalléen 23A, 0373 Oslo, Norway;4. Department of Gynaecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausseen 70, 0379 Oslo, Norway;5. Institute for Cancer Genetics and Informatics, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausseen 70, 0379 Oslo, Norway;6. Department of Medical Physics, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausseen 70, 0379 Oslo, Norway;7. Department of Physics, University of Oslo, Sem Sælands vei 24, 0371 Oslo, Norway
Abstract:High dose rate brachytherapy is a highly conformal method of radiation dose escalation for prostate cancer and one of several treatment options for men with localised disease. The large doses per fraction exploit the low alpha/beta ratio of prostate cancer cells so that biological radiation dose delivered is substantially greater than that achieved with conventional external beam delivery. This review article presents contemporary data on the rationale for high dose rate brachytherapy including treatment technique and future directions.
Keywords:PSA  TRUS  Prostatic  Carcinoma  Treatment  Antigène spécifique de la prostate  Échographie  Traitement  Adénocarcinome prostatique
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