Ki-67、P53及CA153与乳腺癌腋窝淋巴结转移的相关性研究

目的 探讨Ki-67、P53及CA153对乳腺癌腋窝淋巴结转移的预测价值。 方法 选取2015年1月—2018年6月涿州市医院收治的乳腺癌患者168例，根据其是否发生腋窝淋巴结转移分为淋巴结转移组(116例)和淋巴结无转移组(52例)，检测各组Ki-67、P53及CA153表达情况。应用单因素及多因素logistic回归分析分析乳腺癌腋窝淋巴结转移的危险因素。 结果 单因素分析显示，临床分期、肿瘤直径、Ki-67、P53及CA153阳性表达与乳腺癌腋窝淋巴结转移相关，差异有统计学意义(均P<0.05)；而年龄、BMI、是否绝经与乳腺癌腋窝淋巴结转移无关，差异无统计学意义(均P>0.05)。多因素logistic回归分析显示，临床分期(OR=2.307，95% CI:1.485~5.452)、肿瘤直径(OR=1.725，95% CI:1.118~2.974)、Ki-67(OR=3.320，95% CI:2.907~10.781)、P53(OR=1.864，95% CI:1.206~3.224)及CA153(OR=2.113，95% CI:1.390~4.942)阳性表达是乳腺癌腋窝淋巴结转移的危险因素。 结论 临床分期、肿瘤直径、Ki-67、P53及CA153阳性表达是乳腺癌腋窝淋巴结转移的危险因素，对预测腋窝淋巴结转移具有一定的价值。 

Study on the correlation between Ki-67, P53 and CA153 and axillary lymph node metastasis of breast cancer

Objective To investigate the predictive value of Ki-67, P53 and CA153 in axillary lymph node metastasis of breast cancer. Methods We selected 168 breast cancer patients admitted to Zhuozhou hospital from January 2015 to June 2018. They were divided into lymph node metastasis group (n=116) and no lymph node metastasis group (n=52) according to whether they had axillary lymph node metastasis, and the expressions of ki-67, P53 and CA153 in each group were detected. Analysis of risk factors of axillary lymph node metastasis in breast cancer was made via univariate and multivariate logistic regression. Results Univariate analysis showed that clinical stage, tumor diameter, Ki-67, P53 and CA153 positive expression were correlated with axillary lymph node metastasis of breast cancer (P<0.05), while age, BMI, clinical stage and pathological type were not correlated with axillary lymph node metastasis of breast cancer (P>0.05). Multivariate logistic regression analysis showed that clinical stage (OR=2.307, 95% CI: 1.485-5.452), tumor diameter (OR=1.725, 95% CI:1.118-2.974), Ki-67 (OR=3.320, 95% CI: 2.907-10.781), P53 (OR=1.864, 95% CI: 1.206-3.224) and CA 153 (OR=2.113, 95% CI: 1.390-4.942) positive expression were risk factors for axillary lymph node metastasis. Conclusion Clinical stage, tumor diameter, positive expression of Ki-67, P53 and CA153 are risk factors for axillary lymph node metastasis of breast cancer, which had certain value in predicting axillary lymph node metastasis.