| 外泌体在肿瘤发病过程中的作用 |
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| 引用本文： | 张丽娜,许昕瑜,郭松佳,任云青.外泌体在肿瘤发病过程中的作用[J].现代肿瘤医学,2019,0(15):2791-2795. |
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| 作者姓名： | 张丽娜 许昕瑜 郭松佳 任云青 |
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| 作者单位： | 1.山西医科大学汾阳学院，山西 汾阳 032200；2.山西省人民医院肾脏病分子诊断与治疗实验室，山西 太原 030000 |
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| 基金项目： | National Natural Science Foundation of China（No.81603020）;国家自然科学青年基金（编号:81603020）；山西省青年科学基金（编号:201601D021108） |
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| 摘 要： | 外泌体(exosome，EXOs)是细胞内的多泡体与质膜融合后释放的、富含蛋白质、核酸的物质。外泌体特异性膜结构及内容物在肿瘤细胞间的物质交换及信息交流中发挥重要作用，在细胞与微环境之间起到桥梁连接的作用。同时，外泌体在调节肿瘤细胞增殖、凋亡、侵袭、转移及肿瘤耐药等方面也发挥着重要作用。因此，针对外泌体的研究将为临床肿瘤的治疗提供新思路。本文就外泌体在肿瘤发病机制中的研究进行综述。
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| 关 键 词： | 外泌体 肿瘤细胞 增殖 凋亡 侵袭 转移 肿瘤耐药 |
Research progress of exosomes in tumor cells |
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| Zhang Lina,Xu Xinyu,Guo Songjia,Ren Yunqing.Research progress of exosomes in tumor cells[J].Journal of Modern Oncology,2019,0(15):2791-2795. |
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| Authors: | Zhang Lina Xu Xinyu Guo Songjia Ren Yunqing |
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| Institution: | 1.Fenyang College of Shanxi Medical University，Shanxi Fenyang 032200，China；2.Laboratory of Molecular Diagnosis and Treatment of Kidney Diseases，Shanxi Provincial People's Hospital，Shanxi Taiyuan 030000，China. |
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| Abstract: | Exosome (EXOs) are proteins and nucleic acid-rich substances released by fusion of multivesicular bodies and plasma membranes in cells.The exosome-specific membrane structure and contents play an important role in the material exchange and information exchange between tumor cells，and play a role of bridge connection between the cells and the microenvironment.At the same time，exosomes also play an important role in regulating tumor cell proliferation，apoptosis，invasion，metastasis and tumor resistance.Therefore，research on exosomes will provide new ideas for the treatment of clinical tumors.This article reviews the research of exosomes in the pathogenesis of tumor cells. |
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| Keywords: | exosomes tumor cells proliferation apoptosis invasion metastasis tumor resistance |
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