东升扶桑饮对痰湿型勃起功能障碍患者内皮功能保护作用的临床研究

目的 探讨东升扶桑饮对痰湿型勃起功能障碍患者内皮功能的保护作用。 方法 选取2018年3—7月来江苏省中医院就诊的痰湿型勃起功能障碍患者60例，采用随机数字表法分为对照组和观察组，各30例，对照组口服他达那非治疗，观察组在对照组基础上加入东升扶桑饮，比较2组治疗前后的临床疗效、内皮功能相关指标和不良反应发生率。 结果 治疗前，2组患者国际勃起功能评分表(IIEF-5)评分、中医症状评分和最大勃起硬度比较差异无统计学意义(均P>0.05)，治疗后，2组的IIEF-5评分、中医症状评分和最大勃起硬度明显优于治疗前(均P<0.05)，且观察组的上述指标明显优于对照组(均P<0.05)。治疗前，2组的血管扩张功能(FMD)、一氧化氮(NO)、内皮素-1(ET-1)水平比较差异无统计学意义(均P>0.05)，治疗后，2组的FMD和NO水平明显高于治疗前(均P<0.05)，且观察组的FMD和NO水平明显高于对照组(均P<0.05)，2组的ET-1水平明显低于治疗前(P<0.05)，且观察组的ET-1水平明显低于对照组(P<0.05)。2组患者治疗期间均未出现头痛、视线模糊及药物过敏等明显不良反应，观察组仅有1例患者出现轻微胃肠道不适症状，2组患者不良反应发生情况差异无统计学意义(P>0.05)。 结论 东升扶桑饮能够显著改善痰湿型勃起功能障碍患者的临床症状，并对患者的内皮功能具有一定的保护作用，且安全性较高。 

Protective effect of Dongsheng Fusang decoction on endothelial function in phlegm-dampness type erectile dysfunction patient

Objective To explore the protective effect of Dongsheng Fusang decoction on endothelial function in phlegm-dampness type erectile dysfunction patients. Methods A total of 60 patients with phlegm-dampness type erectile dysfunction in our hospital were selected from March 2018 to July 2018,and they were randomly divided into control group (n=30) and observation group (n=30) according to the random number table method. The control group was treated with Tadalafil, and the observation group was took the Dongsheng Fusang decoction on the control group. The clinical efficacy, endothelial function related indexes and incidence of adverse reactions were compared between the two groups before and after treatment. Results Before treatment, there was no statistically significant difference in international erectile function scale (IIEF-5) score, TCM symptom score and maximum erectile hardness between the two groups (P>0.05), after treatment,the IIEF-5score, TCM symptom score and maximum erectile hardness of the two groups were significantly better than those before treatment(P<0.05), and the above indexes in the observation group were obviously better than those in the control group (P<0.05). Before treatment, there was no statistically significant difference in the levels of vasodilatory function (FMD), nitric oxide (NO) and endothelin-1 (ET-1) between the two groups (P>0.05), after treatment, the levels of FMD and NO in the two groups were significantly higher than those before treatment (P<0.05), and the levels of these two indexes in the observation group were significantly higher than those in the control group (P<0.05), the level of ET-1 in the two groups was significantly lower than that before treatment (P<0.05), and the level of ET-1 in the observation group was significantly lower than that in the control group (P<0.05). No obvious adverse reactions such as headache, blurred vision and drug allergy were observed in either group during the treatment. Only one patient in the observation group presented mild gastrointestinal discomfort symptoms, adverse reactions in the two groups were not statistically significant (P>0.05). Conclusion Dongsheng Fu sang Yin can significantly improve the clinical efficacy of phlegm-dampness type erectile dysfunction patients and it has certain protective effect on endothelial function of patients, which is worth popularizing in clinical treatment, and has a high safety.