增生性玻璃体视网膜病变中调控上皮间质转化的研究进展

增生性玻璃体视网膜病变是眼外伤和视网膜脱离常见的并发症,可造成视力不可逆转的急剧下降。手术治疗的高复发率促使学者们积极寻求有效的药物辅助治疗方法。虽然该病的发病机制至今仍未完全阐明,但研究表明,视网膜色素上皮细胞经历的上皮-间质转化过程是其发病的关键步骤。近年来学者们对上皮-间质转化在增生性玻璃体视网膜病变中所涉及的信号通路、增殖作用和纤维化、能量代谢和氧化应激、表观遗传以及中药提取物等多方面做了大量研究,本文将对此展开综述。

Advances in the regulation of epithelial-mesenchymal transition in Proliferative vitreoretinopathy

Proliferative vitreoretinopathy is a common complication of ocular trauma and retinal detachment,which can result in irreversible and sharp loss of vision.The high recurrence rate of surgical treatment has prompted scholars to actively seek effective drug-assisted treatment.Although the pathogenesis of the disease has not yet been fully elucidated,studies have shown that the epithelial-mesenchymal transition process experienced by retinal pigment epithelial cells is a critical step in its pathogenesis.In recent years,scholars have done a lot of research on the signaling pathway,proliferation and fibrosis,energy metabolism and oxidative stress,epigenetic and traditional Chinese medicine extracts involved in epithelial-mesenchymal transition in proliferative vitreoretinopathy.This article will provide an overview of this development.