青光眼角膜生物力学与视盘生物力学的关系

【目的】探索青光眼患者角膜生物力学与视盘生物力学间的关系。【方法】前瞻性病例观察研究。观察32例原发性开角型青光眼（POAG）患者、20例正常眼压性青光眼（NTG）患者、15例高眼压症（OHT）者和26例正常者的角膜生物力学参数及筛板厚度特征，评估测量筛板厚度（LCT）的可重复性，采用单因素方差分析比较不同类型青光眼者间筛板厚度差异，并应用Spearman相关分析方法分析角膜生物力学参数与筛板厚度相关性。【结果】扫频OCT所测量筛板厚度的Cronbach′sα系数0.911，组内相关系数ICC也大于0.8，重复性较好。POAG、NTG患者LCT较OHT患者和正常者偏薄（P<0.05）。OHT与正常者间LCT未见明显统计学差异（P=0.653）。LCT与角膜生物力学参数最大变形幅度（DA）、最大压陷时间（HCT）、第二次压平速度（A2V）及最大压陷屈膝峰间距（PD）间存在明显相关性。【结论】筛板厚度在青光眼患者中具有特征性，是青光眼疾病的重要参数。且LCT与角膜生物力学代表性参数间存在明显相关，角膜生物力学具备评估视盘生物力学的可能。

Correlations between the Biomechanical Properties of Cornea and Optic Nerve Head in Glaucoma

【Objective】 To examine a potential correlation between corneal biomechanical properties with lamina cribrosa thickness.【Methods】Thirty-two patients with POAG，20 with NTG，15 with OHT and 26 healthy controls were included in the cross- sectional study. The parameters of corneal biomechanical properties and lamina cribrosa thickness were compared among POAG，NTG，OHT and healthy subjects by mixed-model analysis of variance（ANOVA）. Spearman′ s coefficient of rank correlation analysis was used to assess the association between parameters of deformation response and clinical factors. 【Results】 The Cronbach′ s α of lamina cribrosa thickness was 0.911，and ICC was more than 0.8. Laminar thickness was thinner in the POAG and NTG groups than in the OHT group and Normal group（P < 0.05）. There were no significant differences between OHT and normal groups（P = 0.653）. Correlation analysis showed that LCT and some important corneal biomechanical properties had significant correlation （P = 0.000）. 【Conclusions】 LCT showed different characteristic in glaucoma，and it may be an important factor for glaucoma progression. LCT and corneal biomechanical properties showed significant correlation ，and corneal biomechanical properties may be used to evaluate the biomechanical properties of optic nerve.