低能量超脉冲CO2点阵激光在眼周年轻化治疗中的临床应用

目的：对比30例患者采用低能量超脉冲CO₂点阵激光治疗前后眼周皱纹及眼睑松弛的等级评分，分析低能量超脉冲CO₂点阵激光在眼周年轻化包括改善眼周皱纹和眼睑松弛中的应用效果。方法：选择符合标准的30例眼周皱纹和眼睑松弛患者，采用超脉冲CO₂点阵激光治疗，使用DeepFX手具、能量5 mJ、重复频率600 Hz、10 mm光斑扫描一次，皱纹走行区域用2 mm光斑、相同能量重复治疗1次，由2名资深皮肤科医师依据眼睑松弛量化表在首次治疗前及治疗后7 d、1个月、3个月和6个月进行评分，并进行统计学分析。结果：与治疗前比较，治疗后7 d时患者眼睑松弛量化表评分差异无统计学意义（P>0.05），治疗后1个月时患者眼睑松弛量化表评分明显降低（P<0.05），且治疗后3~6个月时患者眼睑松弛量化表评分进一步降低（P<0.01），效果更明显。本组30例患者治疗后通常会有一过性红斑、肿胀和轻度灼痛，均能耐受，无严重并发症发生。结论：5 mJ低能量超脉冲CO₂点阵激光治疗眼周皱纹和眼睑松弛有效，安全性高，无严重不良反应发生。

Clinical application of ultra-pulsed fractional CO2 laser with lower energy in treatment of periocular rejuvenation

Objective:To compare the scores of periocular wrinkle and blepharochalasis of the patients before and after the treatment of ultra-pulsed fractional CO₂ laser with low energy,and to illuminate the efficacy of ultra-pulsed fractional CO₂ laser with lower energy in eyelid rejuvenation including periocular wrinkle and blepharochalasis. Methods:Thirty patients with periocular wrinkles and blepharochalasis who met the inclusion criteria were selected. The patients were treated with ultra-pulsed fractional CO₂ laser; the laser parameters were 10 mm spot size, pulse energy 5 mJ and repetition rate 600 Hz and the wrinkle walking areas were treated with 2 mm spot size and the same energy again. Two senior dermatologists scored according to the eyelid laxity scale before treatment and 7 d, 1 month, 3 months and 6 months after treatment, and statistical analysis was performed. Results:Compared with before treatment,there was no significant difference in the scores of eyelid laxity scale 7 d after treatment(P>0.05); the score of eyelid laxity scale was significantly decreased 1 month after treatment (P<0.05);the scores of eyelid laxity scale were significantly decreased 3-6 months after treatment (P<0.01),and the curative effect was more obvious.In this group of 30 patients, there were usually transient erythema, swelling and mild burning pain after treatment. But no serious complications occurred. Conclusion:Ultra-pulsed fractional CO₂ laser with lower energy(5 mJ) can improve the periocular wrinkles and blepharochalasis effectively with high security and without severe side effects.