前列腺癌患者免疫功能及其与前列腺癌临床病理特点的关系

目的探讨前列腺癌患者免疫功能及其与前列腺癌临床病理特点的关系。方法选择桐乡市第一人民医院泌尿外科2014年1月-2016年12月前列腺癌患者60例作为前列腺癌组,健康体检者60例作为对照组。采用流式细胞仪检测外周血CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、自然杀伤细胞(natural killer cells,NK)。结果前列腺癌组CD3^+、CD4^+、CD4^+/CD8^+均低于对照组(P<0.05),CD8^+、NK细胞高于对照组(P<0.05)。前列腺癌体积<60 mL患者CD3^+、CD4^+、CD8^+、NK、CD4^+/CD8^+和体积≥60 mL比较差异无统计学意义(P>0.05)。前列腺癌中低分化患者CD3^+、CD4^+、CD4^+/CD8^+低于高分化患者(P<0.05),CD8^+、NK细胞高于高分化患者(P<0.05)。前列腺癌Ⅲ~Ⅳ期患者CD3^+、CD4^+、CD4^+/CD8^+低于Ⅰ~Ⅱ期患者(P<0.05),CD8^+、NK细胞高于Ⅰ~Ⅱ期患者(P<0.05)。前列腺癌有淋巴结转移患者CD3^+、CD4^+、CD4^+/CD8^+低于无淋巴结转移患者(P<0.05),CD8^+、NK细胞高于无淋巴结转移患者(P<0.05)。结论前列腺癌患者存在免疫功能低下,前列腺癌患者的免疫功能低下程度和前列腺癌分化程度、临床分期和淋巴结转移有关,与肿瘤体积无关,前列腺癌分化程度越低、临床分期越高、有淋巴结转移者免疫功能低下程度越高。

Immune function of patients with prostate cancer and its relationship with clinicopathological characteristics of prostate cancer

Objective To explore the immune function of prostate cancer patients and its relationship with clinicopathological features of prostate cancer. Methods Total 60 cases of patients with prostate cancer in our hospital from January 2014 to December 2016 were assigned into the prostate cancer group, and 60 healthy subjects into the control group. The levels of CD4+, CD8+, CD4+/CD8+ and natural killer cells (NK) were detected by using flow cytometry. Results The levels of CD3+, CD4+, and CD4+/CD8+ in prostate cancer group were lower than those in the control group (P<0.05), the levels of CD8+ and NK cells were higher than those in the control group (P<0.05). There was no significant difference in the levels of CD3+, CD4+, CD8+, NK and CD4+/CD8+ between the prostate cancer patients with volume≥60 mL and volume <60 mL (P>0.05). The CD3+, CD4+ and CD4+/CD8+ in the medium-poorly differentiated prostate cancer patients were significantly lower than in well differentiated patients (P<0.05), the CD8+ and NK cells were higher than those in well differentiated patients (P<0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in the stage Ⅰ-Ⅱ prostate cancer patients were lower than those in the stage Ⅰ-Ⅱ patients (P<0.05), the CD8+ and NK cells were higher than those in stage Ⅰ-Ⅱ patients (P<0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in patients with lymph node metastasis were lower than that in patients without lymph node metastasis (P<0.05), the CD8+ and NK cells were higher than those without lymph node metastasis (P<0.05). Conclusion The immune function in prostate cancer patients is low. The low immune function of prostate cancer patients is related to prostate cancer differentiation, clinical stage and lymph node metastasis, and is not related to tumor volume. The lower differentiation, higher clinical stage and lymph node metastasis are closely correlated with the higher degree of immune dysfunction.